Considerations and Caveats in Combating ESKAPE Pathogens Against Nosocomial Infections

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2020 Jan 11

PMID 31921562

Citations 96

Authors

Yu-Xuan Ma

Chen-Yu Wang

Yuan-Yuan Li

Jing Li

Qian-Qian Wan

Ji-Hua Chen

Franklin R Tay

Li-Na Niu

Affiliations

Soon will be listed here.

Abstract

ESKAPE pathogens (, , , , , and species) are among the most common opportunistic pathogens in nosocomial infections. ESKAPE pathogens distinguish themselves from normal ones by developing a high level of antibiotic resistance that involves multiple mechanisms. Contemporary therapeutic strategies which are potential options in combating ESKAPE bacteria need further investigation. Herein, a broad overview of the antimicrobial research on ESKAPE pathogens over the past five years is provided with prospective clinical applications.

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References

Garcia-Lara B, Saucedo-Mora M, Roldan-Sanchez J, Perez-Eretza B, Ramasamy M, Lee J . Inhibition of quorum-sensing-dependent virulence factors and biofilm formation of clinical and environmental Pseudomonas aeruginosa strains by ZnO nanoparticles. Lett Appl Microbiol. 2015; 61(3):299-305. DOI: 10.1111/lam.12456. View

Wang G, Hanke M, Mishra B, Lushnikova T, Heim C, Thomas V . Transformation of human cathelicidin LL-37 into selective, stable, and potent antimicrobial compounds. ACS Chem Biol. 2014; 9(9):1997-2002. PMC: 4168778. DOI: 10.1021/cb500475y. View

Brown P, Dawson M . Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections. J Antibiot (Tokyo). 2017; 70(4):386-394. DOI: 10.1038/ja.2016.146. View

Huang S, Septimus E, Kleinman K, Moody J, Hickok J, Heim L . Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial. Lancet. 2019; 393(10177):1205-1215. PMC: 6650266. DOI: 10.1016/S0140-6736(18)32593-5. View

Durkin M, Corey G . New developments in the management of severe skin and deep skin structure infections - focus on tedizolid. Ther Clin Risk Manag. 2015; 11:857-62. PMC: 4447168. DOI: 10.2147/TCRM.S64553. View

Karlowsky J, Kazmierczak K, Bouchillon S, de Jonge B, Stone G, Sahm D . Activity of Ceftazidime-Avibactam against Clinical Isolates of Enterobacteriaceae and Pseudomonas aeruginosa Collected in Asia-Pacific Countries: Results from the INFORM Global Surveillance Program, 2012 to 2015. Antimicrob Agents Chemother. 2018; 62(7). PMC: 6021687. DOI: 10.1128/AAC.02569-17. View

Malmsten M . Interactions of Antimicrobial Peptides with Bacterial Membranes and Membrane Components. Curr Top Med Chem. 2015; 16(1):16-24. DOI: 10.2174/1568026615666150703121518. View

Lee J, Wu J, Deng Y, Wang J, Wang C, Wang J . A cell-cell communication signal integrates quorum sensing and stress response. Nat Chem Biol. 2013; 9(5):339-43. DOI: 10.1038/nchembio.1225. View

Gonzalez-Bello C . Antibiotic adjuvants - A strategy to unlock bacterial resistance to antibiotics. Bioorg Med Chem Lett. 2017; 27(18):4221-4228. DOI: 10.1016/j.bmcl.2017.08.027. View

10.

Santajit S, Indrawattana N . Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens. Biomed Res Int. 2016; 2016:2475067. PMC: 4871955. DOI: 10.1155/2016/2475067. View

11.

Brannon J, Hadjifrangiskou M . The arsenal of pathogens and antivirulence therapeutic strategies for disarming them. Drug Des Devel Ther. 2016; 10:1795-806. PMC: 4890686. DOI: 10.2147/DDDT.S98939. View

12.

Grinholc M, Nakonieczna J, Fila G, Taraszkiewicz A, Kawiak A, Szewczyk G . Antimicrobial photodynamic therapy with fulleropyrrolidine: photoinactivation mechanism of Staphylococcus aureus, in vitro and in vivo studies. Appl Microbiol Biotechnol. 2015; 99(9):4031-43. PMC: 4428807. DOI: 10.1007/s00253-015-6539-8. View

13.

Pourhajibagher M, Boluki E, Chiniforush N, Pourakbari B, Farshadzadeh Z, Ghorbanzadeh R . Modulation of virulence in Acinetobacter baumannii cells surviving photodynamic treatment with toluidine blue. Photodiagnosis Photodyn Ther. 2016; 15:202-12. DOI: 10.1016/j.pdpdt.2016.07.007. View

14.

Tajuddeen N, Sallau M, Musa A, Yahaya S, Habila J, Ismail A . A novel antimicrobial flavonoid from the stem bark of Commiphora pedunculata (Kotschy & Peyr.) Engl. Nat Prod Res. 2015; 30(10):1109-15. DOI: 10.1080/14786419.2015.1041138. View

15.

Chung P, Khanum R . Antimicrobial peptides as potential anti-biofilm agents against multidrug-resistant bacteria. J Microbiol Immunol Infect. 2017; 50(4):405-410. DOI: 10.1016/j.jmii.2016.12.005. View

16.

Korczowski B, Antadze T, Giorgobiani M, Stryjewski M, Jandourek A, Smith A . A Multicenter, Randomized, Observer-blinded, Active-controlled Study to Evaluate the Safety and Efficacy of Ceftaroline Versus Comparator in Pediatric Patients With Acute Bacterial Skin and Skin Structure Infection. Pediatr Infect Dis J. 2016; 35(8):e239-47. DOI: 10.1097/INF.0000000000001191. View

17.

Hosseininassab Nodoushan S, Yadegari S, Moghim S, Nasr Isfahani B, Fazeli H, Poursina F . Distribution of the Strains of Multidrug-resistant, Extensively Drug-resistant, and Pandrug-resistant Isolates from Burn Patients. Adv Biomed Res. 2017; 6:74. PMC: 5501067. DOI: 10.4103/abr.abr_239_16. View

18.

Sabaeifard P, Abdi-Ali A, Soudi M, Gamazo C, Irache J . Amikacin loaded PLGA nanoparticles against Pseudomonas aeruginosa. Eur J Pharm Sci. 2016; 93:392-8. DOI: 10.1016/j.ejps.2016.08.049. View

19.

Sharma R, Park T, Moy S . Ceftazidime-Avibactam: A Novel Cephalosporin/β-Lactamase Inhibitor Combination for the Treatment of Resistant Gram-negative Organisms. Clin Ther. 2016; 38(3):431-44. DOI: 10.1016/j.clinthera.2016.01.018. View

20.

Lin A, Autran C, Szyszka A, Escajadillo T, Huang M, Godula K . Human milk oligosaccharides inhibit growth of group B . J Biol Chem. 2017; 292(27):11243-11249. PMC: 5500792. DOI: 10.1074/jbc.M117.789974. View