Rack1 Controls Parallel Fiber-Purkinje Cell Synaptogenesis and Synaptic Transmission

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2020 Jan 11

PMID 31920545

Citations 6

Authors

Haihong Yang

Chaojuan Yang

Qian Zhu

Mengping Wei

Ying Li

Juanxian Cheng

Fengjiao Liu

Yan Wu

Jiyan Zhang

Chen Zhang

Haitao Wu

Affiliations

Soon will be listed here.

Abstract

Purkinje cells (PCs) in the cerebellum receive two excitatory afferents including granule cells-derived parallel fiber (PF) and the climbing fiber. Scaffolding protein Rack1 is highly expressed in the cerebellar PCs. Here, we found delayed formation of specific cerebellar vermis lobule and impaired motor coordination in PC-specific Rack1 conditional knockout mice. Our studies further revealed that Rack1 is essential for PF-PC synapse formation. In addition, Rack1 plays a critical role in regulating synaptic plasticity and long-term depression (LTD) induction of PF-PC synapses without changing the expression of postsynaptic proteins. Together, we have discovered Rack1 as the crucial molecule that controls PF-PC synaptogenesis and synaptic plasticity. Our studies provide a novel molecular insight into the mechanisms underlying the neural development and neuroplasticity in the cerebellum.

Citing Articles

The roles of RACK1 in the pathogenesis of Alzheimer's disease.

He W, Shi X, Dong Z J Biomed Res. 2024; 38(2):137-148.

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O-GlcNAcylation Is Required for the Survival of Cerebellar Purkinje Cells by Inhibiting ROS Generation.

Liu F, Li S, Zhao X, Xue S, Li H, Yang G Antioxidants (Basel). 2023; 12(4).

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The coupling of RACK1 with the beta isoform of the glucocorticoid receptor promotes resilience to chronic stress exposure.

Brivio P, Buoso E, Masi M, Gallo M, Gruca P, Lason M Neurobiol Stress. 2021; 15:100372.

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Origins, Development, and Compartmentation of the Granule Cells of the Cerebellum.

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