Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness

Overview

Journal Front Neurosci

Date 2020 Jan 11

PMID 31920501

Citations 4

Authors

Leon Qi Rong Ooi

Ming-Ching Wen

Samuel Yong-Ern Ng

Nicole Shuang-Yu Chia

Isabel Hui Min Chew

Weiling Lee

Zheyu Xu

Septian Hartono

Eng King Tan

Ling Ling Chan

Louis Chew-Seng Tan

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: The underlying neuropathology of excessive daytime sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to investigate neural network changes that underlie EDS in PD.

Methods: Early PD patients comprising eighty-one patients without EDS (EDS-) and seventeen patients with EDS (EDS+) received a resting state functional MRI scan and the Epworth Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), motor and basal ganglia networks were compared between the EDS+ and EDS- groups. Correlations between network connectivity and the severity of EDS were investigated through linear regression.

Results: EDS+ patients displayed a trend of increased network connectivity of the posterior DMN (pDMN). A significant positive correlation was found between connectivity of the ventromedial prefrontal cortex in the pDMN and ESS.

Conclusion: EDS+ patients are likely to display increased activation in the DMN, suggesting neural compensation in early PD or impaired attentiveness due to mechanisms such as mind-wandering.

Citing Articles

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