Retrospective Analysis of Intensity-modulated Radiotherapy and Three-dimensional Conformal Radiotherapy of Postoperative Treatment for Biliary Tract Cancer

Overview

Journal Radiat Oncol J

Specialty Oncology

Date 2020 Jan 11

PMID 31918466

Citations 1

Authors

Hyo Chun Lee

Jong Hoon Lee

Sea-Won Lee

Joo Hwan Lee

Mina Yu

Hong Seok Jang

Sung Hwan Kim

Affiliations

Soon will be listed here.

Abstract

Purpose: This study was conducted to compare the outcome of three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for the postoperative treatment of biliary tract cancer.

Materials And Methods: From February 2008 to June 2016, 57 patients of biliary tract cancer treated with curative surgery followed by postoperative 3D-CRT (n = 27) or IMRT (n = 30) were retrospectively enrolled.

Results: Median follow-up time was 23.6 months (range, 5.2 to 97.6 months) for all patients and 38.4 months (range, 27.0 to 89.2 months) for survivors. Two-year recurrence-free survival is higher in IMRT arm than 3D-CRT arm with a marginal significance (25.9% vs. 47.4%; p = 0.088). Locoregional recurrence-free survival (64.3% vs. 81.7%; p = 0.122) and distant metastasis-free survival (40.3% vs. 55.8%; p = 0.234) at two years did not show any statistical difference between two radiation modalities. In the multivariate analysis, extrahepatic cholangiocarcinoma, poorly-differentiated histologic grade, and higher stage were significant poor prognostic factors for survival. Severe treatment-related toxicity was not significantly different between two arms.

Conclusion: IMRT showed comparable results with 3D-CRT in terms of recurrence, and survival, and radiotherapy toxicity for the postoperative treatment of biliary tract cancer.

Citing Articles

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Xu W, Aikeremu D, Sun J, Zhang Y, Xu J, Zhou W Neural Regen Res. 2020; 16(3):580-586.

PMID: 32985491 PMC: 7996033. DOI: 10.4103/1673-5374.293153.

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