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PBMC Gene Expression Profiles of Female Bangladeshi Adults Chronically Exposed to Arsenic-contaminated Drinking Water

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Journal Environ Pollut
Date 2020 Jan 10
PMID 31918125
Citations 7
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Abstract

Arsenic, a class I human carcinogen, is ubiquitously found throughout the environment and around the globe, posing a great public health concern. Notably, Bangladesh and regions of West Bengal have been found to have high levels (0.5-4600 μg/L) of arsenic drinking water contamination, and approximately 50 million of the world's 200 million people chronically exposed to arsenic in Bangladesh alone. This study was carried out to examine genome-wide gene expression changes in individuals chronically exposed to arsenic-contaminated drinking water. Our study population includes twenty-nine Bangladeshi female participants with urinary arsenic levels ranging from 22.32 to 1828.12 μg/g creatinine. RNA extracted from peripheral blood mononuclear cells (PBMCs) were evaluated using RNA-Sequencing analysis. Our results indicate that a total of 1,054 genes were significantly associated with increasing urinary arsenic levels (FDR p < 0.05), which include 418 down-regulated and 636 up-regulated genes. Further Ingenuity Pathway Analysis revealed potential target genes (DAPK1, EGR2, APP), microRNAs (miR-155, -338, -210) and pathways (NOTCH signaling pathway) related to arsenic carcinogenesis. The selection of female-only participants provides a homogenous study population since arsenic has significant sex dependent effects, and the wide exposure range provides new insight for key gene expression changes that correlate with increasing urinary arsenic levels.

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References
1.
Wu G, Kang H, Zhang X, Shao H, Chu L, Ruan C . A critical review on the bio-removal of hazardous heavy metals from contaminated soils: issues, progress, eco-environmental concerns and opportunities. J Hazard Mater. 2009; 174(1-3):1-8. DOI: 10.1016/j.jhazmat.2009.09.113. View

2.
Ben-Hamo R, Efroni S . MicroRNA regulation of molecular pathways as a generic mechanism and as a core disease phenotype. Oncotarget. 2015; 6(3):1594-604. PMC: 4359317. DOI: 10.18632/oncotarget.2734. View

3.
Warner L, Mancias P, Butler I, McDonald C, Keppen L, Koob K . Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nat Genet. 1998; 18(4):382-4. DOI: 10.1038/ng0498-382. View

4.
Sattler M, Liang H, Nettesheim D, Meadows R, Harlan J, Eberstadt M . Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science. 1997; 275(5302):983-6. DOI: 10.1126/science.275.5302.983. View

5.
Tsang Y, Dogruluk T, Tedeschi P, Wardwell-Ozgo J, Lu H, Espitia M . Functional annotation of rare gene aberration drivers of pancreatic cancer. Nat Commun. 2016; 7:10500. PMC: 4737758. DOI: 10.1038/ncomms10500. View