Stem Cell-derived Cell Sheet Transplantation for Heart Tissue Repair in Myocardial Infarction

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2020 Jan 10

PMID 31915074

Citations 53

Authors

Rui Guo

Masatoshi Morimatsu

Tian Feng

Feng Lan

Dehua Chang

Feng Wan

Yunpeng Ling

Affiliations

Soon will be listed here.

Abstract

Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and scaffold tissue engineering. Furthermore, induced pluripotent stem cell-derived cell sheets have been indicated to possess higher potential for MI therapy than other stem cell-derived sheets because of their capacity to form vascularized networks for fabricating thickened human cardiac tissue and their long-term therapeutic effects after transplantation in MI. To date, stem cell sheet transplantation has exhibited a dramatic role in attenuating cardiac dysfunction and improving clinical manifestations of heart failure in MI. In this review, we retrospectively summarized the current applications and strategy of stem cell-derived cell sheet technology for heart tissue repair in MI.

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