Effect of Monosodium Glutamate on Testicular Tissue of Paclitaxel-treated Mice: An Experimental Study

Overview

Journal Int J Reprod Biomed

Specialty Reproductive Medicine

Date 2020 Jan 9

PMID 31911964

Citations 2

Authors

Davoud Kianifard

Ali Ehsani

Parisa Zeinolabedini Daneshgar

Ghasem Akbari

Seyyed Maysam Mousavi Shoar Ph D Candidate

Affiliations

Soon will be listed here.

Abstract

Background: Paclitaxel (PTX), a chemotherapeutic agent, and monosodium glutamate (MSG) have oxidative effects on testicular tissue.

Objective: In this study, the effects of MSG administration on the exacerbation of testicular tissue alterations related to PTX treatment were evaluated.

Materials And Methods: MSG (30 & 60 mg/kg i.p.) was administrated to six groups (n = 8/each) of adult mice before or after PTX treatment: control, PTX-treated, MSG30 + PTX, MSG60 + PTX, PTX + MSG30, and PTX + MSG60. Following the euthanizing, the body weight measurement, pituitary-testicular axis hormonal analysis and serum lipid peroxidation index assessment was prepared, testicular histomorphometry (tubular diameter and germinal epithelium height), immunohistochemistry of was completed. Microscopic indices of spermatogenesis (tubular differentiation, spermiogenesis and repopulation indices) were studied.

Results: Body weight was not changed significantly. The levels of testosterone (p = 0.0001), follicle stimulating hormone (p = 0.019), and luteinizing hormone (p = 0.08) were decreased while the level of lipid peroxidation index was increased (p = 0.208) in the treated groups. The histomorphometry indices (p 0.0001 and p = 0.001, respectively), germ cells population (p 0.05) and microscopic indices of spermatogenesis (p = 0.001, p = 0.005, p 0.0001, respectively) were significantly reduced in all treated groups. The administration of MSG before PTX treatment induces more changes. The most positive reaction to was observed in MSG30 or 60 + PTX groups compared to other groups.

Conclusion: The administration of MSG could intensify testicular tissue alterations related to PTX chemotherapy.

Citing Articles

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