Changes in Clinical Markers During A Short-Term Transfer Program of Adult Cystic Fibrosis Patients from Pediatric to Adult Care

Overview

Journal Open Respir Med J

Publisher Bentham Open

Specialty Pulmonary Medicine

Date 2020 Jan 8

PMID 31908684

Citations 3

Authors

Matthias Welsner

Sivagurunathan Sutharsan

Christian Taube

Margarete Olivier

Uwe Mellies

Florian Stehling

Affiliations

Soon will be listed here.

Abstract

Background: Transition from child-oriented to adult-oriented health care in Cystic Fibrosis (CF) has become more important over recent decades as the survival of people with this disease has increased. The transition process usually begins in adolescence, with full transfer completed in early adulthood.

Objective: This study investigated the impact of a short-term transfer program on clinical markers in an adult CF cohort still being managed by pediatricians.

Methods: Clinically relevant data from the year before (T-1), the time of Transfer (T) and the year after the transfer (T+1) were analysed retrospectively.

Results: 39 patients (median age 29.0 years; 64% male) were transferred between February and December 2016. Lung function had declined significantly in the year before transfer (in % predicted: Forced Expiratory Volume in 1 second (FEV), 62.8 57.7, <0.05; Forced Vital Capacity (FVC), 79.9 71.1, <0.05), but remained stable in the year after transfer (in % predicted: FEV: 56.3; FVC 68.2). BMI was stable over the whole observational period. There was no relevant change in chronic lung infection with , Methicillin-Resistant Staphylococcus aureus (MRSA) and sp. during the observation period. The number of patient contacts increased significantly in the year after versus the year before transfer (inpatient: 1.51 2.51, <0.05; outpatient: 2.67 3.41, <0.05).

Conclusions: Our data show that, within the framework of a structured transfer process, it is possible to transfer a large number of adult CF patients, outside a classic transition program, from a pediatric to an adult CF center in a short period of time, without any relevant changes in clinical markers and, stability.

Citing Articles

A Global Perspective on Transition Models for Pediatric to Adult Cystic Fibrosis Care: What Has Been Made So Far?.

Poamaneagra S, Plesca D, Tataranu E, Marginean O, Nemtoi A, Mihai C J Clin Med. 2024; 13(23).

PMID: 39685886 PMC: 11642410. DOI: 10.3390/jcm13237428.

Adult healthcare is associated with more emergency healthcare for young people with life-limiting conditions.

Jarvis S, Flemming K, Richardson G, Fraser L Pediatr Res. 2022; 92(5):1458-1469.

PMID: 35152268 PMC: 9700517. DOI: 10.1038/s41390-022-01975-3.

Transition of children with life-limiting conditions to adult care and healthcare use: a systematic review.

Jarvis S, Roberts D, Flemming K, Richardson G, Fraser L Pediatr Res. 2021; 90(6):1120-1131.

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