Inhibition of Duck Hepatitis B Virus Replication by Purine 2',3'-dideoxynucleosides

Overview

Journal Biochem Biophys Res Commun

Publisher Elsevier

Specialty Biochemistry

Date 1988 Nov 15

PMID 3190693

Citations 16

Authors

S Suzuki

B Lee

W Luo

D Tovell

M J Robins

D L Tyrrell

Affiliations

Soon will be listed here.

Abstract

Primary hepatocyte cultures from duck hepatitis B virus (DHBV) infected ducklings were used to evaluate the antiviral activity of purine and pyrimidine 2',3'-dideoxynucleosides. The purine 2',3'-dideoxynucleosides were very effective inhibitors of hepadnavirus replication, whereas the pyrimidine dideoxynucleosides were not. 2',3'-Dideoxyguanosine and 2,6-diaminopurine 2',3'-dideoxyriboside (ddDAPR) were the most effective antiviral agents studied. ddDAPR given intramuscularly twice daily at 10 mg/kg rapidly cleared DHBV-DNA from the sera of persistently infected ducklings but this effect was not permanent.

Citing Articles

Superinfection exclusion in duck hepatitis B virus infection is mediated by the large surface antigen.

Walters K, Joyce M, Addison W, Fischer K, Tyrrell D J Virol. 2004; 78(15):7925-37.

PMID: 15254165 PMC: 446106. DOI: 10.1128/JVI.78.15.7925-7937.2004.

Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening.

Walters K, Tipples G, Allen M, Condreay L, Addison W, Tyrrell L Antimicrob Agents Chemother. 2003; 47(6):1936-42.

PMID: 12760870 PMC: 155849. DOI: 10.1128/AAC.47.6.1936-1942.2003.

The intracellular activation of lamivudine (3TC) and determination of 2'-deoxycytidine-5'-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells.

Kewn S, Hoggard P, Sales S, Johnson M, Back D Br J Clin Pharmacol. 2001; 50(6):597-604.

PMID: 11136299 PMC: 2015020. DOI: 10.1046/j.1365-2125.2000.00302.x.

Pharmacodynamics of (-)-beta-2',3'-dideoxy-3'-thiacytidine in chronically virus-infected woodchucks compared to its pharmacodynamics in humans.

Hurwitz S, Tennant B, Korba B, Gerin J, Schinazi R Antimicrob Agents Chemother. 1998; 42(11):2804-9.

PMID: 9797207 PMC: 105947. DOI: 10.1128/AAC.42.11.2804.

Antisense therapy of hepatitis B virus infection.

Offensperger W, Offensperger S, Blum H Mol Biotechnol. 1998; 9(2):161-70.

PMID: 9658393 DOI: 10.1007/BF02760817.