Lack of Association Between Polymorphism of IL-2 -330T/G and Pulmonary Tuberculosis Among Caucasians

Overview

Journal Innate Immun

Publisher Sage Publications

Specialties Allergy & Immunology
Microbiology

Date 2020 Jan 8

PMID 31906759

Authors

Haibo Ge

Shi Chen

Jia Zhu

Affiliations

Soon will be listed here.

Abstract

This meta-analysis was conducted to assess the consistency and strength of the relationship between polymorphism of IL-2 -330T/G and susceptibility to pulmonary tuberculosis (TB). PubMed, Web of Knowledge and CNKI were searched to find eligible studies about the relationship between IL-2 -330T/G polymorphism and susceptibility to pulmonary TB. A total of eight studies comprising 971 cases and 1519 controls were grouped together for the purpose of elucidating the relationship between polymorphism of IL-2 -330T/G and pulmonary TB susceptibility. The allele model (G vs. T: odds ratio (OR) = 1.34; 95% confidence interval (CI) 1.05-1.71, = 0.001) and the recessive model (GG+GT vs. TT: OR = 1.60; 95% CI 1.08-2.38, = 0.0001) showed an increased risk of development of pulmonary TB. However, the homozygous model (GG vs. TT: OR = 1.74; 95% CI 0.98-3.09, = 0.0005) and the dominant model (GG vs. TT + TG: OR = 1.30; 95% CI = 0.80-2.14, = 0.001) failed to show an increased incidence of pulmonary TB. When analysis was stratified by ethnicity, no obvious associations were identified in the Caucasian subgroup under all four genetic models. Additionally, heterogeneity disappeared in the analysis of Caucasian subgroup. Our combined data suggested that there was no association between IL-2 -330T/G polymorphism and pulmonary TB among Caucasians.

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