Effects of Probiotics on Metabolic Syndrome: A Systematic Review of Randomized Clinical Trials

Overview

Journal Nutrients

Date 2020 Jan 8

PMID 31906372

Citations 45

Authors

Carmen Tenorio-Jimenez

Maria Jose Martinez-Ramirez

Angel Gil

Carolina Gomez-Llorente

Affiliations

Soon will be listed here.

Abstract

The aim of this systematic review is to evaluate whether the use of probiotics has any effect on the components of metabolic syndrome (MetS) before patients develop type 2 diabetes. A qualitative systematic review, following the Cochrane methodology, and a comprehensive literature search of randomized controlled trials (RCTs) were conducted in PubMed and Scopus from inception until 4 July 2019. According to our inclusion criteria, nine clinical studies were finally analyzed, corresponding to six RCTs. Probiotics intake in patients with MetS resulted in improvements in body mass index, blood pressure, glucose metabolism, and lipid profile in some studies. Regarding inflammatory biomarkers, probiotics also positively affected the soluble vascular cell adhesion molecule 1 (sVCAM-1), interleukine-6 (IL-6), tumor necrosis factor α (TNF-α), vascular endothelial growth factor (VEGF), and thrombomodulin. Despite the diversity of the published studies, the intake of probiotics for patients with MetS may offer a discrete improvement in some of the clinical characteristics of the MetS and a decrease in inflammatory biomarkers. Nevertheless, these beneficial effects seem to be marginal compared to drug therapy and a healthy lifestyle and clinically non-relevant.

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References

. 6. Glycemic Targets: . Diabetes Care. 2018; 42(Suppl 1):S61-S70. DOI: 10.2337/dc19-S006. View

Backhed F, Ding H, Wang T, Hooper L, Koh G, Nagy A . The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004; 101(44):15718-23. PMC: 524219. DOI: 10.1073/pnas.0407076101. View

Barnard N, Willett W, Ding E . The Misuse of Meta-analysis in Nutrition Research. JAMA. 2017; 318(15):1435-1436. DOI: 10.1001/jama.2017.12083. View

Szulinska M, Loniewski I, van Hemert S, Sobieska M, Bogdanski P . Dose-Dependent Effects of Multispecies Probiotic Supplementation on the Lipopolysaccharide (LPS) Level and Cardiometabolic Profile in Obese Postmenopausal Women: A 12-Week Randomized Clinical Trial. Nutrients. 2018; 10(6). PMC: 6024794. DOI: 10.3390/nu10060773. View

Stadlbauer V, Leber B, Lemesch S, Trajanoski S, Bashir M, Horvath A . Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study. PLoS One. 2015; 10(10):e0141399. PMC: 4625062. DOI: 10.1371/journal.pone.0141399. View

Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G . Richness of human gut microbiome correlates with metabolic markers. Nature. 2013; 500(7464):541-6. DOI: 10.1038/nature12506. View

Alberti K, Zimmet P, Shaw J . Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 2006; 23(5):469-80. DOI: 10.1111/j.1464-5491.2006.01858.x. View

Barreto F, Simao A, Morimoto H, Lozovoy M, Dichi I, Miglioranza L . Beneficial effects of Lactobacillus plantarum on glycemia and homocysteine levels in postmenopausal women with metabolic syndrome. Nutrition. 2014; 30(7-8):939-42. DOI: 10.1016/j.nut.2013.12.004. View

Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122):1027-31. DOI: 10.1038/nature05414. View

10.

Zimmet P, Alberti K, Stern N, Bilu C, El-Osta A, Einat H . The Circadian Syndrome: is the Metabolic Syndrome and much more!. J Intern Med. 2019; 286(2):181-191. PMC: 6851668. DOI: 10.1111/joim.12924. View

11.

Rezazadeh L, Pourghassem Gargari B, Jafarabadi M, Alipour B . Effects of probiotic yogurt on glycemic indexes and endothelial dysfunction markers in patients with metabolic syndrome. Nutrition. 2019; 62:162-168. DOI: 10.1016/j.nut.2018.12.011. View

12.

Backhed F, Manchester J, Semenkovich C, Gordon J . Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007; 104(3):979-84. PMC: 1764762. DOI: 10.1073/pnas.0605374104. View

13.

Borgeraas H, Johnson L, Skattebu J, Hertel J, Hjelmesaeth J . Effects of probiotics on body weight, body mass index, fat mass and fat percentage in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2017; 19(2):219-232. DOI: 10.1111/obr.12626. View

14.

Plovier H, Cani P . Microbial Impact on Host Metabolism: Opportunities for Novel Treatments of Nutritional Disorders?. Microbiol Spectr. 2017; 5(3). PMC: 11687490. DOI: 10.1128/microbiolspec.BAD-0002-2016. View

15.

Alberti K, Eckel R, Grundy S, Zimmet P, Cleeman J, Donato K . Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation;.... Circulation. 2009; 120(16):1640-5. DOI: 10.1161/CIRCULATIONAHA.109.192644. View

16.

Kojic Damjanov S, deric M, Kojic N . Glycated hemoglobin A1c as a modern biochemical marker of glucose regulation. Med Pregl. 2014; 67(9-10):339-44. View

17.

Tripolt N, Leber B, Blattl D, Eder M, Wonisch W, Scharnagl H . Short communication: Effect of supplementation with Lactobacillus casei Shirota on insulin sensitivity, β-cell function, and markers of endothelial function and inflammation in subjects with metabolic syndrome--a pilot study. J Dairy Sci. 2012; 96(1):89-95. DOI: 10.3168/jds.2012-5863. View

18.

Szulinska M, Loniewski I, Skrypnik K, Sobieska M, Korybalska K, Suliburska J . Multispecies Probiotic Supplementation Favorably Affects Vascular Function and Reduces Arterial Stiffness in Obese Postmenopausal Women-A 12-Week Placebo-Controlled and Randomized Clinical Study. Nutrients. 2018; 10(11). PMC: 6265939. DOI: 10.3390/nu10111672. View

19.

Turnbaugh P, Hamady M, Yatsunenko T, Cantarel B, Duncan A, Ley R . A core gut microbiome in obese and lean twins. Nature. 2008; 457(7228):480-4. PMC: 2677729. DOI: 10.1038/nature07540. View

20.

Dabke K, Hendrick G, Devkota S . The gut microbiome and metabolic syndrome. J Clin Invest. 2019; 129(10):4050-4057. PMC: 6763239. DOI: 10.1172/JCI129194. View