Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies

Overview

Journal Vaccines (Basel)

Date 2020 Jan 8

PMID 31906351

Citations 15

Authors

Christoph Kreer

Henning Gruell

Thierry Mora

Aleksandra M Walczak

Florian Klein

Affiliations

Soon will be listed here.

Abstract

The human antibody repertoire is generated by the recombination of different gene segments as well as by processes of somatic mutation. Together these mechanisms result in a tremendous diversity of antibodies that are able to combat various pathogens including viruses and bacteria, or malignant cells. In this review, we summarize the opportunities and challenges that are associated with the analyses of the B cell receptor repertoire and the antigen-specific B cell response. We will discuss how recent advances have increased our understanding of the antibody response and how repertoire analyses can be exploited to inform on vaccine strategies, particularly against HIV-1.

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