The Nuclear Phosphoinositide Response to Stress

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2020 Jan 7

PMID 31902273

Citations 16

Authors

Mo Chen

Tianmu Wen

Hudson T Horn

Vishwanatha K Chandrahas

Narendra Thapa

Suyong Choi

Vincent L Cryns

Richard A Anderson

Affiliations

Soon will be listed here.

Abstract

Accumulating evidence reveals that nuclear phosphoinositides (PIs) serve as central signaling hubs that control a multitude of nuclear processes by regulating the activity of nuclear proteins. In response to cellular stressors, PIs accumulate in the nucleus and multiple PI isomers are synthesized by the actions of PI-metabolizing enzymes, kinases, phosphatases and phospholipases. By directly interacting with effector proteins, phosphoinositide signals transduce changes in cellular functions. Here we describe nuclear phosphoinositide signaling in multiple sub-nuclear compartments and summarize the literature that demonstrates roles for specific kinases, phosphatases, and phospholipases in the orchestration of nuclear phosphoinositide signaling in response to cellular stress. Additionally, we discuss the specific PI-protein complexes through which these lipids execute their functions by regulating the configuration, stability, and transcription activity of their effector proteins. Overall, our review provides a detailed landscape of the current understanding of the nuclear PI-protein interactome and its role in shaping the coordinated response to cellular stress.

Citing Articles

Phosphoinositide signaling in the nucleus: Impacts on chromatin and transcription regulation.

Hifdi N, Vaucourt M, Hnia K, Panasyuk G, Vandromme M Biol Cell. 2024; 117(1):e2400096.

PMID: 39707648 PMC: 11771838. DOI: 10.1111/boc.202400096.

Linking Phosphoinositides to Proteins: A Novel Signaling PIPeline.

Carrillo N, Awasthi P, Lee J, Wen T, Chen M, Sterling C J Cell Signal. 2024; 5(3):114-121.

PMID: 39582486 PMC: 11584056. DOI: 10.33696/signaling.5.118.

Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer.

Jung O, Baek M, Wooldrik C, Johnson K, Fisher K, Lou J EMBO J. 2024; 43(9):1740-1769.

PMID: 38565949 PMC: 11066040. DOI: 10.1038/s44318-024-00085-6.

Membranes are functionalized by a proteolipid code.

Kervin T, Overduin M BMC Biol. 2024; 22(1):46.

PMID: 38414038 PMC: 10898092. DOI: 10.1186/s12915-024-01849-6.

Environmental pollutants and phosphoinositide signaling in autoimmunity.

Ren C, Carrillo N, Cryns V, Anderson R, Chen M J Hazard Mater. 2023; 465:133080.

PMID: 38091799 PMC: 10923067. DOI: 10.1016/j.jhazmat.2023.133080.

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