Short-term Resistance Exercise Inhibits Neuroinflammation and Attenuates Neuropathological Changes in 3xTg Alzheimer's Disease Mice

Overview

Journal J Neuroinflammation

Publisher Biomed Central

Date 2020 Jan 5

PMID 31900170

Citations 44

Authors

Yan Liu

John Man Tak Chu

Tim Yan

Yan Zhang

Ying Chen

Raymond Chuen Chung Chang

Gordon Tin Chun Wong

Affiliations

Soon will be listed here.

Abstract

Background: Both human and animal studies have shown beneficial effects of physical exercise on brain health but most tend to be based on aerobic rather than resistance type regimes. Resistance exercise has the advantage of improving both muscular and cardiovascular function, both of which can benefit the frail and the elderly. However, the neuroprotective effects of resistance training in cognitive impairment are not well characterized.

Methods: We evaluated whether short-term resistant training could improve cognitive function and pathological changes in mice with pre-existing cognitive impairment. Nine-month-old 3xTg mouse underwent a resistance training protocol of climbing up a 1-m ladder with a progressively heavier weight loading.

Results: Compared with sedentary counterparts, resistance training improved cognitive performance and reduced neuropathological and neuroinflammatory changes in the frontal cortex and hippocampus of mice. In line with these results, inhibition of pro-inflammatory intracellular pathways was also demonstrated.

Conclusions: Short-term resistance training improved cognitive function in 3xTg mice, and conferred beneficial effects on neuroinflammation, amyloid and tau pathology, as well as synaptic plasticity. Resistance training may represent an alternative exercise strategy for delaying disease progression in Alzheimer's disease.

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