Transcriptome Changes Induced by in Cervical Cancer Cells

Overview

Journal Oncol Lett

Specialty Oncology

Date 2020 Jan 4

PMID 31897181

Authors

Qian-Qian Gao

Bin Zhou

Xiu-Zhang Yu

Zhu Zhang

Yan-Yun Wang

Ya-Ping Song

Lin Zhang

Hong Luo

Ming-Rong Xi

Affiliations

Soon will be listed here.

Abstract

Runt-related transcription factor 3 () is a member of Runt domain family that is known to play key roles in various different types of tumor. It was recently demonstrated that may also be associated with cervical cancer. The aim of the present study was to investigate the potential association between transcriptome changes and expression in cervical cancer. A overexpression model was constructed using cervical cancer cell lines by plasmid transfection. It was demonstrated that the upregulated expression of inhibited proliferation of cervical cancer cell lines, particularly SiHa cells, and was associated with the expression of the and genes. In addition, it was revealed that the and pathways may also be affected by . Therefore, the expression of the gene may be involved in the occurrence and progression of cervical cancer.

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