Antidepressant-induced Reduction in Betel-quid Use in Patients with Depression: A Pioneer Clinical Study

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2020 Jan 3

PMID 31895834

Citations 9

Authors

Chung-Chieh Hung

Chien-Hung Lee

Chia-Min Chung

Srinivasan Nithiyanantham

Hsien-Yuan Lane

Ying-Chin Ko

Affiliations

Soon will be listed here.

Abstract

Betel-quid is commonly used around the world and is listed as a Group I carcinogen. Prior research has suggested a possible association between antidepressants and betel-quid use. We aimed to clarify the effects of antidepressant therapy in betel-quid chewers in the population of patients with depression.We enrolled 204 patients with depressive disorders, collected their demographic information, and administered the Substance Use Severity Rating Scale for alcohol, cigarettes, and betel-quid and the Hamilton Depression Rating Scale. We compared betel-quid and non-betel-quid chewers and examined the effects of antidepressant therapy on betel-quid abstinence after previous exposure to betel-quid.Patients with depression were reported a higher prevalence of 26% betel-quid chewing habits and patients who chewed betel-quid showed more severe depressive symptoms. After antidepressant therapy, the addictiveness of betel-quid was significantly reduced by 4 times.This was a pioneering study showing that antidepressants could be a candidate for betel-quid cessation therapy. Future clinical trials are needed to verify their efficacy in reducing consumption for betel-quid addiction treatment.

Citing Articles

Selective Serotonin Reuptake Inhibitors for Cessation of Betel Quid Use in Patients with Major Depressive Disorder in Taiwan.

Hung C, Tu H, Chung C Biomedicines. 2024; 12(11).

PMID: 39595197 PMC: 11591801. DOI: 10.3390/biomedicines12112633.

Impact of MAOA Gene Polymorphism on the Efficacy of Antidepressant Treatment and Craving Severity for Betel Quid Use Disorder.

Hung C, Ko Y, Chen P, Chung C Int J Mol Sci. 2024; 25(17).

PMID: 39273170 PMC: 11394840. DOI: 10.3390/ijms25179221.

Biological Effects and Biomedical Applications of Areca Nut and Its Extract.

Tong T, Xu A, Tan S, Jiang H, Liu L, Deng S Pharmaceuticals (Basel). 2024; 17(2).

PMID: 38399443 PMC: 10893415. DOI: 10.3390/ph17020228.

Association between Single Nucleotide Polymorphisms in Monoamine Oxidase and the Severity of Addiction to Betel Quid.

Hung C, Ko Y, Chung C Curr Issues Mol Biol. 2024; 46(2):1010-1019.

PMID: 38392182 PMC: 10887354. DOI: 10.3390/cimb46020064.

Systematic Review of Roles of Arecoline and Arecoline -Oxide in Oral Cancer and Strategies to Block Carcinogenesis.

Ko A, Tu H, Ko Y Cells. 2023; 12(8).

PMID: 37190117 PMC: 10137008. DOI: 10.3390/cells12081208.

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