Effect of Selenium Supplementation on Glycemic Indices: a Meta-analysis of Randomized Controlled Trials

Overview

Journal J Diabetes Metab Disord

Specialty Endocrinology

Date 2020 Jan 1

PMID 31890660

Citations 9

Authors

Armita Mahdavi Gorabi

Motahareh Hasani

Shirin Djalalinia

Maryam Zarei

Hanieh Ejtahed

Mohammad Esmaeili Abdar

Hamid Asayesh

Mehdi Azimzadeh

Mostafa Qorbani

Mehdi Noroozi

Affiliations

Soon will be listed here.

Abstract

Purpose: The association between selenium supplementation and glycemic indices seems to be a controversial issue. This systematic review and meta-analysis was conducted to evaluate the effect of selenium supplementation on glycemic indices.

Methods: We systematically searched PubMed/MEDLINE, ISI/WOS, and Scopus (from their commencements up to Jan 2016) for relevant studies examining the association between intake of selenium and glycemic indices. The data were extracted from relevant qualified studies and estimated using the random-effect or pooled model and standardized mean difference (SMD) with 95% confidence interval (CI).

Results: Twelve articles published between 2004 and 2016 were included. In all the studies, the participants were randomly assigned to an intervention group ( = 757) or a control group( = 684). All the studies were double blind, placebo controlled trials. Selenium supplementation resulted in a significant decrease in homeostasis model of assessment-estimated β-cell function (HOMA-B) (SMD: -0.63; 95%CI: -0.89 to -0.38) and a significant increase in quantitative insulin sensitivity check index (QUICKI) (SMD: by 0.74; 95%CI: 0.49 to 0.1) as compared with the controls. There were no statistically significant improvements in glycemic indices, such as fasting plasma glucose (FPG), insulin, homeostasis model of assessment-estimated insulin resistance (HOMA-IR), Hemoglobin A1c (HbA1c) and adiponectin.

Conclusion: This meta-analysis indicated that selenium supplementation significantly decreased HOMA-B and increased QUICKI score. There was no statistically significant improvement in FPG, insulin, HOMA-IR, HbA1c and adiponectin indices following selenium supplementation.

Citing Articles

Differential association of selenium exposure with insulin resistance and β-cell function in middle age and older adults.

Rodriguez-Hernandez Z, Bel-Aguilar J, Moreno-Franco B, Grau-Perez M, Redon J, Gomez-Ariza J Nutr Diabetes. 2025; 15(1):5.

PMID: 39948355 PMC: 11825691. DOI: 10.1038/s41387-025-00361-2.

Serum Selenium Levels and Their Relationship with Insulin Resistance in Individuals with Polycystic Ovary Syndrome.

Karami M, Almaghrabi S, Banasr O, Hussein K Biol Trace Elem Res. 2024; .

PMID: 39500832 DOI: 10.1007/s12011-024-04435-7.

Selenium Species in Diabetes Mellitus Type 2.

Pyrzynska K, Sentkowska A Biol Trace Elem Res. 2023; 202(7):2993-3004.

PMID: 37880477 PMC: 11074226. DOI: 10.1007/s12011-023-03900-z.

Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses.

Wang P, Chen B, Huang Y, Li J, Cao D, Chen Z Front Nutr. 2023; 10:1263853.

PMID: 37781125 PMC: 10534049. DOI: 10.3389/fnut.2023.1263853.

Effects of Selenium Supplementation on the Indices of Disease Activity, Inflammation and Oxidative Stress in Patients with Rheumatoid Arthritis: a Randomized Clinical Trial.

Zamani B, Taghvaee F, Akbari H, Mohtashamian A, Sharifi N Biol Trace Elem Res. 2023; 202(4):1457-1467.

PMID: 37477848 DOI: 10.1007/s12011-023-03782-1.

References

Jamilian M, Razavi M, Fakhrie Kashan Z, Ghandi Y, Bagherian T, Asemi Z . Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2014; 82(6):885-91. DOI: 10.1111/cen.12699. View

Nikuei P, Davoodian N, Tahamtan I, Keshtkar A . Predictive value of miR-210 as a novel biomarker for pre-eclampsia: a systematic review protocol. BMJ Open. 2016; 6(9):e011920. PMC: 5051509. DOI: 10.1136/bmjopen-2016-011920. View

DIPLOCK A . Antioxidants and disease prevention. Mol Aspects Med. 1994; 15(4):293-376. DOI: 10.1016/0098-2997(94)90005-1. View

Mao J, Bath S, Vanderlelie J, Perkins A, Redman C, Rayman M . No effect of modest selenium supplementation on insulin resistance in UK pregnant women, as assessed by plasma adiponectin concentration. Br J Nutr. 2015; 115(1):32-8. DOI: 10.1017/S0007114515004067. View

Wang C, Yang S, Zhang N, Mu Y, Ren H, Wang Y . Long-term supranutritional supplementation with selenate decreases hyperglycemia and promotes fatty liver degeneration by inducing hyperinsulinemia in diabetic db/db mice. PLoS One. 2014; 9(7):e101315. PMC: 4077766. DOI: 10.1371/journal.pone.0101315. View

Kohler L, Foote J, Kelley C, Florea A, Shelly C, Chow H . Selenium and Type 2 Diabetes: Systematic Review. Nutrients. 2018; 10(12). PMC: 6316380. DOI: 10.3390/nu10121924. View

Duntas L . Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm Metab Res. 2009; 41(6):443-7. DOI: 10.1055/s-0029-1220724. View

Liu R, Li X, Zhang Z, Zhou M, Sun Y, Su D . Allogeneic mesenchymal stem cells inhibited T follicular helper cell generation in rheumatoid arthritis. Sci Rep. 2015; 5:12777. PMC: 4531289. DOI: 10.1038/srep12777. View

Bahmani F, Kia M, Soleimani A, Asemi Z, Esmaillzadeh A . Effect of Selenium Supplementation on Glycemic Control and Lipid Profiles in Patients with Diabetic Nephropathy. Biol Trace Elem Res. 2015; 172(2):282-289. DOI: 10.1007/s12011-015-0600-4. View

10.

Alizadeh M, Safaeiyan A, Ostadrahimi A, Estakhri R, Daneghian S, Ghaffari A . Effect of L-arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: a randomized, double-blind, placebo-controlled trial. Ann Nutr Metab. 2012; 60(2):157-68. DOI: 10.1159/000335470. View

11.

Katsuki A, Sumida Y, Gabazza E, Murashima S, Furuta M, Hori Y . Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes. Diabetes Care. 2001; 24(2):362-5. DOI: 10.2337/diacare.24.2.362. View

12.

Zhou J, Huang K, Lei X . Selenium and diabetes--evidence from animal studies. Free Radic Biol Med. 2013; 65:1548-1556. PMC: 3859733. DOI: 10.1016/j.freeradbiomed.2013.07.012. View

13.

DerSimonian R, Laird N . Meta-analysis in clinical trials. Control Clin Trials. 1986; 7(3):177-88. DOI: 10.1016/0197-2456(86)90046-2. View

14.

Hatfield D, Gladyshev V . The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology. Mol Interv. 2009; 9(1):18-21. PMC: 2718722. DOI: 10.1124/mi.9.1.6. View

15.

Faghihi T, Radfar M, Barmal M, Amini P, Qorbani M, Abdollahi M . A randomized, placebo-controlled trial of selenium supplementation in patients with type 2 diabetes: effects on glucose homeostasis, oxidative stress, and lipid profile. Am J Ther. 2013; 21(6):491-5. DOI: 10.1097/MJT.0b013e318269175f. View

16.

Ju W, Li X, Li Z, Wu G, Fu X, Yang X . The effect of selenium supplementation on coronary heart disease: A systematic review and meta-analysis of randomized controlled trials. J Trace Elem Med Biol. 2017; 44:8-16. DOI: 10.1016/j.jtemb.2017.04.009. View

17.

Farrokhian A, Bahmani F, Taghizadeh M, Mirhashemi S, Aarabi M, Raygan F . Selenium Supplementation Affects Insulin Resistance and Serum hs-CRP in Patients with Type 2 Diabetes and Coronary Heart Disease. Horm Metab Res. 2016; 48(4):263-8. DOI: 10.1055/s-0035-1569276. View

18.

Hoffmann F, Hashimoto A, Shafer L, Dow S, Berry M, Hoffmann P . Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols. J Nutr. 2010; 140(6):1155-61. PMC: 2869499. DOI: 10.3945/jn.109.120725. View

19.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

20.

Campbell S, Aldibbiat A, Marriott C, Landy C, Ali T, Ferris W . Selenium stimulates pancreatic beta-cell gene expression and enhances islet function. FEBS Lett. 2008; 582(15):2333-7. DOI: 10.1016/j.febslet.2008.05.038. View