» Articles » PMID: 31888919

Unexpected Rupture of an Expectantly Managed Tubal Ectopic Pregnancy: a Reminder for Enhanced Diligence

Overview
Journal BMJ Case Rep
Specialty General Medicine
Date 2020 Jan 1
PMID 31888919
Authors
Affiliations
Soon will be listed here.
Abstract

Expectant management of tubal ectopic pregnancies is a feasible and possibly preferable method of management in asymptomatic women with low serum β-human chorionic gonadotropin (hCG). This involves serial monitoring of β-hCG until negative, after which it is deemed as spontaneously resolved ectopic pregnancy. We describe a case of tubal ectopic pregnancy which was expectantly managed with an initial β-hCG of 585 mIU/mL until undetectable. This patient presented with ruptured ectopic pregnancy 8 weeks after the original diagnosis, at the level of 5 mIU/mL. This highlights the importance of close monitoring in the expectant management of tubal ectopic pregnancies, with the incorporation of imaging, even when serial β-hCG shows a persistently reducing trend.

References
1.
Kooi S, KOCK H, van Etten F . Tubal rupture despite low and declining serum hCG levels. Eur J Obstet Gynecol Reprod Biol. 1992; 46(1):56-9. DOI: 10.1016/0028-2243(92)90281-3. View

2.
Elson J, Tailor A, Banerjee S, Salim R, Hillaby K, Jurkovic D . Expectant management of tubal ectopic pregnancy: prediction of successful outcome using decision tree analysis. Ultrasound Obstet Gynecol. 2004; 23(6):552-6. DOI: 10.1002/uog.1061. View

3.
Jurkovic D, Memtsa M, Sawyer E, Donaldson A, Jamil A, Schramm K . Single-dose systemic methotrexate vs expectant management for treatment of tubal ectopic pregnancy: a placebo-controlled randomized trial. Ultrasound Obstet Gynecol. 2016; 49(2):171-176. DOI: 10.1002/uog.17329. View

4.
van Mello N, Mol F, Verhoeve H, van Wely M, Adriaanse A, Boss E . Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hCG concentrations? A randomized comparison. Hum Reprod. 2012; 28(1):60-7. DOI: 10.1093/humrep/des373. View

5.
. Diagnosis and Management of Ectopic Pregnancy: Green-top Guideline No. 21. BJOG. 2016; 123(13):e15-e55. DOI: 10.1111/1471-0528.14189. View