A Model System for Studying Superselective Radiotherapy of Lymph Node Metastasis in Mice with Swollen Lymph Nodes

Overview

Journal Clin Transl Radiat Oncol

Specialty Oncology

Date 2019 Dec 31

PMID 31886422

Citations 5

Authors

Ryohei Kikuchi

Ariunbuyan Sukhbaatar

Maya Sakamoto

Shiro Mori

Tetsuya Kodama

Affiliations

Soon will be listed here.

Abstract

Utilizing mice with swollen lymph nodes, we succeeded in irradiating individual metastatic lymph nodes through a hole in a lead shield. This system enabled us to increase the radiation dose to >8 Gy (the lethal dose for total-body irradiation) and evaluate both direct and abscopal antitumor effects.

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