Histological and Transmission Electron Microscopy Results After Embolization with HydroSoft/HydroFrame Coils in Experimental Swine Aneurysm

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2019 Dec 31

PMID 31886218

Citations 1

Authors

Seisuke Iseki

Yumiko Mitome-Mishima

Ikuko Ogino

Yasuo Suga

Kenji Yatomi

Senshu Nonaka

Nobukazu Miyamoto

Akihide Kondo

Munetaka Yamamoto

Hajime Arai

Hidenori Oishi

Affiliations

Soon will be listed here.

Abstract

Coiling and clipping are standard treatment strategies for cerebral aneurysms. Regardless of the strategy used, recanalization may affect the patient's prognosis. The aim of this study was to histologically and morphologically compare the tissue proliferation after coil embolization using bare platinum coils versus second-generation hydrogel coils (HydroSoft/HydroFrame; MicroVention, Inc., Aliso Viejo, CA, USA). Endothelial-like cell proliferation was seen in both groups at 2 weeks after surgery. Macroscopic findings showed a tighter layer at 4 weeks in the hydrogel coil group, and histological and immunohistochemical findings revealed endothelial cell proliferation. This layer became much thicker and tighter at 4 weeks after surgery. Aneurysms treated with second-generation hydrogel coils may be more stable and have a lower incidence of recanalization than those treated with bare platinum coils because of the tight endothelial layer proliferation.

Citing Articles

Imaging of intracranial aneurysms in animals: a systematic review of modalities.

Cayron A, Morel S, Allemann E, Bijlenga P, Kwak B Neurosurg Rev. 2023; 46(1):56.

PMID: 36786880 PMC: 9928939. DOI: 10.1007/s10143-023-01953-1.

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