Repeated Live Imaging in the Temporomandibular Joint of an Anterior Crossbite Mouse Model Using a 7T Magnetic Resonance Device

Overview

Journal In Vivo

Specialty Oncology

Date 2019 Dec 29

PMID 31882467

Citations 1

Authors

K O Ito

Fumie Yamazaki

Shinnosuke Nogami

Kosuke Takahashi

Toshirou Kondoh

Alastair Goss

Affiliations

Soon will be listed here.

Abstract

Background/aim: Few studies have performed magnetic resonance (MR) imaging on live animals. The aim of this study was to perform 7T MR microimaging of the temporomandibular joint (TMJ) multiple times in the same living mice with malocclusion, and to compare between MR imaging and histopathological findings.

Materials And Methods: Mice were examined by MR imaging at 3-4, 6 and 12 weeks following the attachment of a metal tube on the left mandibular incisor. Histopathological examination was done at 3, 6 and 12 weeks.

Results: The detailed structure of the TMJ was evident from MR microimaging. The histopathological examination showed some changes in the cartilage, but no changes in the bone structure of these mice.

Conclusion: We successfully performed multiple 7T MR imaging in living mice. Even if the TMJ showed no obvious changes on MR images, minute changes may be present in the cartilage.

Citing Articles

Condylar Resorption Following Compressive Mechanical Stress in Rabbit Model - Association of Matrix Metalloproteinases.

Nogami S, Kataoka Y, Yamauchi K, Yanagisawa Y, Imoto K, Kumasaka A In Vivo. 2022; 36(5):2126-2133.

PMID: 36099088 PMC: 9463924. DOI: 10.21873/invivo.12938.

References

Sperry M, Kartha S, Winkelstein B, Granquist E . Experimental Methods to Inform Diagnostic Approaches for Painful TMJ Osteoarthritis. J Dent Res. 2019; 98(4):388-397. PMC: 6429670. DOI: 10.1177/0022034519828731. View

Lee P, Stanton A, Schumacher A, Truelove E, Hollender L . Osteoarthritis of the temporomandibular joint and increase of the horizontal condylar angle: a longitudinal study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019; 127(4):339-350. DOI: 10.1016/j.oooo.2018.12.014. View

Long X, Goss A . A sheep model of intracapsular condylar fracture. J Oral Maxillofac Surg. 2007; 65(6):1102-8. DOI: 10.1016/j.joms.2006.06.307. View

Sawada K, Amemiya T, Hirai S, Hayashi Y, Suzuki T, Honda M . Diagnostic reliability of 3.0-T MRI for detecting osseous abnormalities of the temporomandibular joint. J Oral Sci. 2018; 60(1):137-141. DOI: 10.2334/josnusd.16-0838. View

Cledes G, Felizardo R, Foucart J, Carpentier P . Validation of a chemical osteoarthritis model in rabbit temporomandibular joint: a compliment to biomechanical models. Int J Oral Maxillofac Surg. 2006; 35(11):1026-33. DOI: 10.1016/j.ijom.2006.05.003. View

Kaduk W, Koppe T . Metric analysis of the upper space of the temporomandibular joint (TMJ) in pigs (Sus scrofa domestica) for evaluation of the pig as a model for arthroscopic TMJ surgery. Ann Anat. 2007; 189(4):367-70. DOI: 10.1016/j.aanat.2007.02.015. View

Yamazaki F, Satoh K, Seo Y . Structure and Size-selective Permeability of the Synovial Membrane of the Temporomandibular Joint of the Mouse Measured by MR Imaging at 7T. Magn Reson Med Sci. 2014; 14(2):115-22. DOI: 10.2463/mrms.2014-0058. View

Kubota Y, Takatsuka S, Nakagawa K, Yamamoto E . A model for temporomandibular joint disc repositioning surgery. J Oral Maxillofac Surg. 2001; 59(12):1443-51. DOI: 10.1053/joms.2001.28279. View

Wang X, Kou X, Mao J, Gan Y, Zhou Y . Sustained inflammation induces degeneration of the temporomandibular joint. J Dent Res. 2012; 91(5):499-505. PMC: 3327731. DOI: 10.1177/0022034512441946. View

10.

Liu Y, Liao L, Zhang H, Lu L, Jiao K, Zhang M . Reducing dietary loading decreases mouse temporomandibular joint degradation induced by anterior crossbite prosthesis. Osteoarthritis Cartilage. 2013; 22(2):302-12. PMC: 4111231. DOI: 10.1016/j.joca.2013.11.014. View

11.

Kyllar M, Putnova B, Jekl V, Stehlik L, Buchtova M, Stembirek J . Diagnostic imaging modalities and surgical anatomy of the temporomandibular joint in rabbits. Lab Anim. 2017; 52(1):38-50. DOI: 10.1177/0023677217702178. View

12.

Polat M, Yanik S . Efficiency of arthrocentesis treatment for different temporomandibular joint disorders. Int J Oral Maxillofac Surg. 2019; 49(5):621-627. DOI: 10.1016/j.ijom.2019.08.017. View

13.

Meng F, Hu K, Kong L, Zhao Y, Liu Y, Zhou S . Morphological evaluation of temporomandibular joint after open and closed treatment of type B diacapsular condylar fractures in sheep. Ann Anat. 2009; 191(3):288-93. DOI: 10.1016/j.aanat.2008.12.002. View

14.

Embree M, Iwaoka G, Kong D, Martin B, Patel R, Lee A . Soft tissue ossification and condylar cartilage degeneration following TMJ disc perforation in a rabbit pilot study. Osteoarthritis Cartilage. 2015; 23(4):629-39. PMC: 4368469. DOI: 10.1016/j.joca.2014.12.015. View

15.

Manoliu A, Spinner G, Wyss M, Erni S, Ettlin D, Nanz D . Quantitative and qualitative comparison of MR imaging of the temporomandibular joint at 1.5 and 3.0 T using an optimized high-resolution protocol. Dentomaxillofac Radiol. 2015; 45(1):20150240. PMC: 5083893. DOI: 10.1259/dmfr.20150240. View

16.

Duygu G, Guler N, Cam B, Kurkcu M . The effects of high molecular weight hyaluronic acid (Hylan G-F 20) on experimentally induced temporomandibular joint osteoartrosis: part II. Int J Oral Maxillofac Surg. 2011; 40(12):1406-13. DOI: 10.1016/j.ijom.2011.07.909. View