On the Magnetic Field Dependence of Deuterium Metabolic Imaging

Overview

Journal NMR Biomed

Publisher Wiley

Date 2019 Dec 28

PMID 31879985

Citations 28

Authors

Robin A de Graaf

Arjan D Hendriks

Dennis W J Klomp

Chathura Kumaragamage

Dimitri Welting

Catalina S Arteaga de Castro

Peter B Brown

Scott McIntyre

Terence W Nixon

Jeanine J Prompers

Henk M De Feyter

Affiliations

Soon will be listed here.

Abstract

Deuterium metabolic imaging (DMI) is a novel MR-based method to spatially map metabolism of deuterated substrates such as [6,6'- H ]-glucose in vivo. Compared with traditional C-MR-based metabolic studies, the MR sensitivity of DMI is high due to the larger H magnetic moment and favorable T and T relaxation times. Here, the magnetic field dependence of DMI sensitivity and transmit efficiency is studied on phantoms and rat brain postmortem at 4, 9.4 and 11.7 T. The sensitivity and spectral resolution on human brain in vivo are investigated at 4 and 7 T before and after an oral dose of [6,6'- H ]-glucose. For small animal surface coils (Ø 30 mm), the experimentally measured sensitivity and transmit efficiency scale with the magnetic field to a power of +1.75 and -0.30, respectively. These are in excellent agreement with theoretical predictions made from the principle of reciprocity for a coil noise-dominant regime. For larger human surface coils (Ø 80 mm), the sensitivity scales as a +1.65 power. The spectral resolution increases linearly due to near-constant linewidths. With optimal multireceiver arrays the acquisition of DMI at a nominal 1 mL spatial resolution is feasible at 7 T.

Citing Articles

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Simultaneous assessment of cerebral glucose and oxygen metabolism and perfusion in rats using interleaved deuterium (H) and oxygen-17 (O) MRS.

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Human Brain Deuterium Metabolic Imaging at 7 T: Impact of Different [6,6'-H]Glucose Doses.

Ahmadian N, Konig M, Otto S, Tesselaar K, van Eijsden P, Gosselink M J Magn Reson Imaging. 2024; 61(3):1170-1178.

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Advances and prospects in deuterium metabolic imaging (DMI): a systematic review of in vivo studies.

Pan F, Liu X, Wan J, Guo Y, Sun P, Zhang X Eur Radiol Exp. 2024; 8(1):65.

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