Exercise As a Favorable Non-pharmacologic Treatment to Sleep-Related Movement Disorders: a Review

Overview

Journal Sleep Sci

Publisher Thieme

Date 2019 Dec 28

PMID 31879545

Citations 7

Authors

Beatriz Franco

Paulo Daubian-Nose

Marco Tulio De-Mello

Andrea Maculano Esteves

Affiliations

Soon will be listed here.

Abstract

Non-pharmacologic treatments of Sleep-Related Movement Disorders (SRMD) are already well described in the literature. The physical activity has been presented as a factor to improve quality of life and in several aspects related to sleep disorders. Thus, the purpose of this review was to analyze the benefits of physical exercise and your indication to improve to SRMD. In the research, 19 studies were found that evaluate the efficacy of physical exercise on SRMD in both human and animal models. The results demonstrate that both acute and chronic physical exercises are effective in reducing symptoms of SRMD. However, most studies were performed with aerobic exercise. Three studies evaluated the efficacy of combined exercise, and no studies have investigated the relationship of resistance exercise. Regarding the mechanisms involved, a study discusses the relationship between the release of beta-endorphin and the exercise practice, and two studies with animal models show the changes of the dopaminergic system after physical exercise. From this evidences, we suggested that physical exercise is a favorable non-pharmacological treatment for SRMD. However, more studies should be available for a better understanding of the molecular mechanisms involved, as well of the type, duration and better time of the day to practice.

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References

de Mello M, Lauro F, Silva A, Tufik S . Incidence of periodic leg movements and of the restless legs syndrome during sleep following acute physical activity in spinal cord injury subjects. Spinal Cord. 1996; 34(5):294-6. DOI: 10.1038/sc.1996.53. View

Connor J, Wang X, Allen R, Beard J, Wiesinger J, Felt B . Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome. Brain. 2009; 132(Pt 9):2403-12. PMC: 2732265. DOI: 10.1093/brain/awp125. View

de Mello M, Silva A, Esteves A, Tufik S . Reduction of periodic leg movement in individuals with paraplegia following aerobic physical exercise. Spinal Cord. 2002; 40(12):646-9. DOI: 10.1038/sj.sc.3101381. View

Montplaisir J, Boucher S, Poirier G, Lavigne G, Lapierre O, Lesperance P . Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord. 1997; 12(1):61-5. DOI: 10.1002/mds.870120111. View

Ondo W . Restless legs syndrome: pathophysiology and treatment. Curr Treat Options Neurol. 2014; 16(11):317. DOI: 10.1007/s11940-014-0317-2. View

Cavagnolli D, Esteves A, Castiglione M, Batista I, Bressan R, Tufik S . Dopamine transporter shown by SPECT in patients with periodic leg movement after acute physical exercise. Med Sci Sports Exerc. 2012; 45(2):224-9. DOI: 10.1249/MSS.0b013e318270306c. View

Earley C, Connor J, Garcia-Borreguero D, Jenner P, Winkelman J, Zee P . Altered brain iron homeostasis and dopaminergic function in Restless Legs Syndrome (Willis-Ekbom Disease). Sleep Med. 2014; 15(11):1288-301. DOI: 10.1016/j.sleep.2014.05.009. View

Allen R, Connor J, Hyland K, Earley C . Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesis. Sleep Med. 2008; 10(1):123-8. PMC: 2655320. DOI: 10.1016/j.sleep.2007.11.012. View

Giannaki C, Sakkas G, Hadjigeorgiou G, Karatzaferi C, Patramani G, Lavdas E . Non-pharmacological management of periodic limb movements during hemodialysis session in patients with uremic restless legs syndrome. ASAIO J. 2011; 56(6):538-42. DOI: 10.1097/MAT.0b013e3181f1cc04. View

10.

Aukerman M, Aukerman D, Bayard M, Tudiver F, Thorp L, Bailey B . Exercise and restless legs syndrome: a randomized controlled trial. J Am Board Fam Med. 2006; 19(5):487-93. DOI: 10.3122/jabfm.19.5.487. View

11.

Pigeon W, Yurcheshen M . Behavioral Sleep Medicine Interventions for Restless Legs Syndrome and Periodic Limb Movement Disorder. Sleep Med Clin. 2010; 4(4):487-494. PMC: 2805158. DOI: 10.1016/j.jsmc.2009.07.008. View

12.

Ohayon M, OHara R, Vitiello M . Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med Rev. 2011; 16(4):283-95. PMC: 3204316. DOI: 10.1016/j.smrv.2011.05.002. View

13.

Giannaki C, Hadjigeorgiou G, Karatzaferi C, Maridaki M, Koutedakis Y, Founta P . A single-blind randomized controlled trial to evaluate the effect of 6 months of progressive aerobic exercise training in patients with uraemic restless legs syndrome. Nephrol Dial Transplant. 2013; 28(11):2834-40. DOI: 10.1093/ndt/gft288. View

14.

Kuchukhidze G, Toidze I, Khatiashvili I, Maisuradze L, Frauscher B, Kasradze S . Prevalence of restless legs syndrome in a Georgian primary healthcare setting: a pilot study. Eur Neurol. 2012; 68(3):177-80. DOI: 10.1159/000337938. View

15.

Esteves A, Lopes C, Frussa-Filho R, Frank M, Cavagnolli D, Arida R . Spontaneously hypertensive rats: possible animal model of sleep-related movement disorders. J Mot Behav. 2013; 45(6):487-93. DOI: 10.1080/00222895.2013.833079. View

16.

Bega D, Malkani R . Alternative treatment of restless legs syndrome: an overview of the evidence for mind-body interventions, lifestyle interventions, and neutraceuticals. Sleep Med. 2016; 17:99-105. DOI: 10.1016/j.sleep.2015.09.009. View

17.

Sakkas G, Hadjigeorgiou G, Karatzaferi C, Maridaki M, Giannaki C, Mertens P . Intradialytic aerobic exercise training ameliorates symptoms of restless legs syndrome and improves functional capacity in patients on hemodialysis: a pilot study. ASAIO J. 2008; 54(2):185-90. DOI: 10.1097/MAT.0b013e3181641b07. View

18.

Stefansson H, Rye D, Hicks A, Petursson H, Ingason A, Thorgeirsson T . A genetic risk factor for periodic limb movements in sleep. N Engl J Med. 2007; 357(7):639-47. DOI: 10.1056/NEJMoa072743. View

19.

Giannaki C, Sakkas G, Karatzaferi C, Maridaki M, Koutedakis Y, Hadjigeorgiou G . Combination of Exercise Training and Dopamine Agonists in Patients with RLS on Dialysis: A Randomized, Double-Blind Placebo-Controlled Study. ASAIO J. 2015; 61(6):738-41. DOI: 10.1097/MAT.0000000000000271. View

20.

Esteves A, de Mello M, Pradella-Hallinan M, Tufik S . Effect of acute and chronic physical exercise on patients with periodic leg movements. Med Sci Sports Exerc. 2008; 41(1):237-42. DOI: 10.1249/MSS.0b013e318183bb22. View