Panel 7 - Pathogenesis of Otitis Media - a Review of the Literature Between 2015 and 2019

Overview

Journal Int J Pediatr Otorhinolaryngol

Specialty Pediatrics

Date 2019 Dec 28

PMID 31879085

Citations 5

Authors

R B Thornton

A Hakansson

D W Hood

J Nokso-Koivisto

D Preciado

K Riesbeck

P C Richmond

Y C Su

W E Swords

K L Brockman

Affiliations

Soon will be listed here.

Abstract

Objective: To perform a comprehensive review of the literature from July 2015 to June 2019 on the pathogenesis of otitis media. Bacteria, viruses and the role of the microbiome as well as the host response are discussed. Directions for future research are also suggested.

Data Sources: PubMed database of the National Library of Medicine.

Review Methods: PubMed was searched for any papers pertaining to OM pathogenesis between July 2015 and June 2019. If in English, abstracts were assessed individually for their relevance and included in the report. Members of the panel drafted the report based on these searches and on new data presented at the 20th International Symposium on Recent Advances in Otitis Media.

Conclusions: The main themes that arose in OM pathogenesis were around the need for symptomatic viral infections to develop disease. Different populations potentially having different mechanisms of pathogenesis. Novel bacterial otopathogens are emerging and need to be monitored. Animal models need to continue to be developed and used to understand disease pathogenesis.

Implications For Practice: The findings in the pathogenesis panel have several implications for both research and clinical practice. The most urgent areas appear to be to continue monitoring the emergence of novel otopathogens, and the need to develop prevention and preventative therapies that do not rely on antibiotics and protect against the development of the initial OM episode.

Citing Articles

Predominant Bacterial and Viral Otopathogens Identified Within the Respiratory Tract and Middle Ear of Urban Australian Children Experiencing Otitis Media Are Diversely Distributed.

Ngo C, Massa H, McMonagle B, Perry C, Nissen M, Sloots T Front Cell Infect Microbiol. 2022; 12:775535.

PMID: 35360096 PMC: 8963760. DOI: 10.3389/fcimb.2022.775535.

Editorial: Otitis Media Genomics and the Middle Ear Microbiome.

Santos-Cortez R, Ehrlich G, Ryan A Front Genet. 2021; 12:763688.

PMID: 34712274 PMC: 8546293. DOI: 10.3389/fgene.2021.763688.

Nontypeable P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance.

Thofte O, Bettoni S, Su Y, Thegerstrom J, Jonsson S, Mattsson E J Immunol. 2021; 207(6):1566-1577.

PMID: 34433620 PMC: 8428749. DOI: 10.4049/jimmunol.2100105.

An Organ System-Based Synopsis of Virulence.

Morin C, Deziel E, Gauthier J, Levesque R, Lau G Virulence. 2021; 12(1):1469-1507.

PMID: 34180343 PMC: 8237970. DOI: 10.1080/21505594.2021.1926408.

Niche- and Gender-Dependent Immune Reactions in Relation to the Microbiota Profile in Pediatric Patients with Otitis Media with Effusion.

Enoksson F, Rodriguez A, Peno C, Balcazar Lopez C, Tjernstrom F, Bogaert D Infect Immun. 2020; 88(10).

PMID: 32661126 PMC: 7504947. DOI: 10.1128/IAI.00147-20.

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