Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2019 Dec 28

PMID 31878082

Citations 90

Authors

Erika Cione

Chiara La Torre

Roberto Cannataro

Maria Cristina Caroleo

Pierluigi Plastina

Luca Gallelli

Affiliations

Soon will be listed here.

Abstract

Epidemiologic studies suggest that dietary polyphenol intake is associated with a lower incidence of several non-communicable diseases. Although several foods contain complex mixtures of polyphenols, numerous factors can affect their content. Besides the well-known capability of these molecules to act as antioxidants, they are able to interact with cell-signaling pathways, modulating gene expression, influencing the activity of transcription factors, and modulating microRNAs. Here we deeply describe four polyphenols used as nutritional supplements: quercetin, resveratrol, epigallocatechin gallate (ECGC), and curcumin, summarizing the current knowledge about them, spanning from dietary sources to the epigenetic capabilities of these compounds on microRNA modulation.

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