Effects of Collagen Hydrolysates on Human Brain Structure and Cognitive Function: A Pilot Clinical Study

Overview

Journal Nutrients

Date 2019 Dec 28

PMID 31878021

Citations 4

Authors

Seiko Koizumi

Naoki Inoue

Fumihito Sugihara

Michiya Igase

Affiliations

Soon will be listed here.

Abstract

This study investigated the effects of collagen hydrolysates (CH) on language cognitive function and brain structure. In this open-label study, 5 g CH was administered once a day for 4 weeks to 30 healthy participants aged 49-63 years. The primary outcome measures were the brain healthcare quotients based on gray matter volume (GM-BHQ) and fractional anisotropy (FA-BHQ). The secondary outcome measures were changes in scores between week 0 and week 4 for word list memory (WLM) and standard verbal paired associate learning (S-PA) tests as well as changes in the physical, mental, and role/social component summary scores of the Short Form-36(SF-36) quality of life instrument. CH ingestion resulted in significant improvements in FA-BHQ ( = 0.0095), a measure of brain structure, as well in scores for the WLM ( = 0.0046) and S-PA ( = 0.0007) tests, which measure cognitive function. There were moderate correlations between the change in WLM score and the change in GM-BHQ ( = 0.4448; Spearman's rank correlation) and between the change in S-PA score and the change in FA-BHQ ( = 0.4645). Daily ingestion of CH changed brain structure and improved language cognitive function.

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