Somatic Mosaicism: Implications for the Cardiovascular System

Overview

Journal Eur Heart J

Publisher Oxford University Press

Specialty Cardiology & Vascular Diseases

Date 2019 Dec 27

PMID 31876923

Citations 8

Authors

Soichi Sano

Ying Wang

Kenneth Walsh

Affiliations

Soon will be listed here.

Citing Articles

Molecular Damage in Aging.

Gladyshev V, Kritchevsky S, Clarke S, Cuervo A, Fiehn O, de Magalhaes J Nat Aging. 2023; 1(12):1096-1106.

PMID: 36846190 PMC: 9957516. DOI: 10.1038/s43587-021-00150-3.

High-level gonosomal mosaicism for a pathogenic non-coding CNV deletion of the lung-specific FOXF1 enhancer in an unaffected mother of an infant with ACDMPV.

Yildiz Bolukbasi E, Karolak J, Szafranski P, Gambin T, Willard N, Abman S Mol Genet Genomic Med. 2022; 10(11):e2062.

PMID: 36124617 PMC: 9651602. DOI: 10.1002/mgg3.2062.

Clonal Hematopoiesis Analyses in Clinical, Epidemiologic, and Genetic Aging Studies to Unravel Underlying Mechanisms of Age-Related Dysfunction in Humans.

Walsh K, Raghavachari N, Kerr C, Bick A, Cummings S, Druley T Front Aging. 2022; 3:841796.

PMID: 35821803 PMC: 9261374. DOI: 10.3389/fragi.2022.841796.

Cardiovascular Disease in Myeloproliferative Neoplasms: State-of-the-Art Review.

Leiva O, Hobbs G, Ravid K, Libby P JACC CardioOncol. 2022; 4(2):166-182.

PMID: 35818539 PMC: 9270630. DOI: 10.1016/j.jaccao.2022.04.002.

Detection of low-level parental somatic mosaicism for clinically relevant SNVs and indels identified in a large exome sequencing dataset.

Domogala D, Gambin T, Zemet R, Wu C, Schulze K, Yang Y Hum Genomics. 2021; 15(1):72.

PMID: 34930489 PMC: 8686574. DOI: 10.1186/s40246-021-00369-6.

References

Genovese G, Kahler A, Handsaker R, Lindberg J, Rose S, Bakhoum S . Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N Engl J Med. 2014; 371(26):2477-87. PMC: 4290021. DOI: 10.1056/NEJMoa1409405. View

Martincorena I, Fowler J, Wabik A, Lawson A, Abascal F, Hall M . Somatic mutant clones colonize the human esophagus with age. Science. 2018; 362(6417):911-917. PMC: 6298579. DOI: 10.1126/science.aau3879. View

Sano S, Oshima K, Wang Y, Katanasaka Y, Sano M, Walsh K . CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease. Circ Res. 2018; 123(3):335-341. PMC: 6054544. DOI: 10.1161/CIRCRESAHA.118.313225. View

Mas-Peiro S, Hoffmann J, Fichtlscherer S, Dorsheimer L, Rieger M, Dimmeler S . Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation. Eur Heart J. 2019; 41(8):933-939. PMC: 7033916. DOI: 10.1093/eurheartj/ehz591. View

Zink F, Stacey S, Norddahl G, Frigge M, Magnusson O, Jonsdottir I . Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly. Blood. 2017; 130(6):742-752. PMC: 5553576. DOI: 10.1182/blood-2017-02-769869. View

Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P, McLaren S . Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin. Science. 2015; 348(6237):880-6. PMC: 4471149. DOI: 10.1126/science.aaa6806. View

Lodato M, Rodin R, Bohrson C, Coulter M, Barton A, Kwon M . Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 2017; 359(6375):555-559. PMC: 5831169. DOI: 10.1126/science.aao4426. View

Yokoyama A, Kakiuchi N, Yoshizato T, Nannya Y, Suzuki H, Takeuchi Y . Age-related remodelling of oesophageal epithelia by mutated cancer drivers. Nature. 2019; 565(7739):312-317. DOI: 10.1038/s41586-018-0811-x. View

Manavski Y, Lucas T, Glaser S, Dorsheimer L, Gunther S, Braun T . Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization. Circ Res. 2018; 122(5):670-677. DOI: 10.1161/CIRCRESAHA.117.312310. View

10.

BENDITT E, Benditt J . Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci U S A. 1973; 70(6):1753-6. PMC: 433588. DOI: 10.1073/pnas.70.6.1753. View

11.

Yizhak K, Aguet F, Kim J, Hess J, Kubler K, Grimsby J . RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues. Science. 2019; 364(6444). PMC: 7350423. DOI: 10.1126/science.aaw0726. View

12.

Lodato M, Woodworth M, Lee S, Evrony G, Mehta B, Karger A . Somatic mutation in single human neurons tracks developmental and transcriptional history. Science. 2015; 350(6256):94-98. PMC: 4664477. DOI: 10.1126/science.aab1785. View

13.

Zhu M, Lu T, Jia Y, Luo X, Gopal P, Li L . Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease. Cell. 2019; 177(3):608-621.e12. PMC: 6519461. DOI: 10.1016/j.cell.2019.03.026. View

14.

Fuster J, MacLauchlan S, Zuriaga M, Polackal M, Ostriker A, Chakraborty R . Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science. 2017; 355(6327):842-847. PMC: 5542057. DOI: 10.1126/science.aag1381. View

15.

Dorsheimer L, Assmus B, Rasper T, Ortmann C, Ecke A, Abou-El-Ardat K . Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure. JAMA Cardiol. 2018; 4(1):25-33. PMC: 6439691. DOI: 10.1001/jamacardio.2018.3965. View

16.

Chappell J, Harman J, Narasimhan V, Yu H, Foote K, Simons B . Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models. Circ Res. 2016; 119(12):1313-1323. PMC: 5149073. DOI: 10.1161/CIRCRESAHA.116.309799. View

17.

Jaiswal S, Natarajan P, Silver A, Gibson C, Bick A, Shvartz E . Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. N Engl J Med. 2017; 377(2):111-121. PMC: 6717509. DOI: 10.1056/NEJMoa1701719. View

18.

Sano S, Oshima K, Wang Y, MacLauchlan S, Katanasaka Y, Sano M . Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome. J Am Coll Cardiol. 2018; 71(8):875-886. PMC: 5828038. DOI: 10.1016/j.jacc.2017.12.037. View

19.

Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman P, Mar B . Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014; 371(26):2488-98. PMC: 4306669. DOI: 10.1056/NEJMoa1408617. View

20.

Jacobsen K, Lund M, Shim J, Gunnersen S, Fuchtbauer E, Kjolby M . Diverse cellular architecture of atherosclerotic plaque derives from clonal expansion of a few medial SMCs. JCI Insight. 2017; 2(19). PMC: 5841865. DOI: 10.1172/jci.insight.95890. View