Mechanisms of Oral Bacterial Virulence Factors in Pancreatic Cancer

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2019 Dec 24

PMID 31867287

Citations 8

Authors

Zhong Sun

Chenglong Xiong

Seoh Wei Teh

Jonathan Chee Woei Lim

Suresh Kumar

Karuppiah Thilakavathy

Affiliations

Soon will be listed here.

Abstract

Pancreatic cancer is a highly lethal disease, and most patients remain asymptomatic until the disease enters advanced stages. There is lack of knowledge in the pathogenesis, effective prevention and early diagnosis of pancreatic cancer. Recently, bacteria were found in pancreatic tissue that has been considered sterile before. The distribution of flora in pancreatic cancer tissue was reported to be different from normal pancreatic tissue. These abnormally distributed bacteria may be the risk factors for inducing pancreatic cancer. Therefore, studies on combined effect of multi-bacterial and multi-virulence factors may add to the knowledge of pancreatic cancer pathogenesis and aid in designing new preventive and therapeutic strategies. In this review, we outlined three oral bacteria associated with pancreatic cancer and their virulence factors linked with cancer.

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References

Moffatt C, Lamont R . Porphyromonas gingivalis induction of microRNA-203 expression controls suppressor of cytokine signaling 3 in gingival epithelial cells. Infect Immun. 2011; 79(7):2632-7. PMC: 3191996. DOI: 10.1128/IAI.00082-11. View

Aykut B, Pushalkar S, Chen R, Li Q, Abengozar R, Kim J . The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature. 2019; 574(7777):264-267. PMC: 6858566. DOI: 10.1038/s41586-019-1608-2. View

Pushalkar S, Hundeyin M, Daley D, Zambirinis C, Kurz E, Mishra A . The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression. Cancer Discov. 2018; 8(4):403-416. PMC: 6225783. DOI: 10.1158/2159-8290.CD-17-1134. View

Rubinstein M, Wang X, Liu W, Hao Y, Cai G, Han Y . Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe. 2013; 14(2):195-206. PMC: 3770529. DOI: 10.1016/j.chom.2013.07.012. View

Riquelme E, Zhang Y, Zhang L, Montiel M, Zoltan M, Dong W . Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes. Cell. 2019; 178(4):795-806.e12. PMC: 7288240. DOI: 10.1016/j.cell.2019.07.008. View

Coppe J, Desprez P, Krtolica A, Campisi J . The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5:99-118. PMC: 4166495. DOI: 10.1146/annurev-pathol-121808-102144. View

Ge Z, Rogers A, Feng Y, Lee A, Xu S, Taylor N . Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. Cell Microbiol. 2007; 9(8):2070-80. DOI: 10.1111/j.1462-5822.2007.00939.x. View

Kamisawa T, Wood L, Itoi T, Takaori K . Pancreatic cancer. Lancet. 2016; 388(10039):73-85. DOI: 10.1016/S0140-6736(16)00141-0. View

Rawla P, Sunkara T, Gaduputi V . Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors. World J Oncol. 2019; 10(1):10-27. PMC: 6396775. DOI: 10.14740/wjon1166. View

10.

Cuevas-Ramos G, Petit C, Marcq I, Boury M, Oswald E, Nougayrede J . Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells. Proc Natl Acad Sci U S A. 2010; 107(25):11537-42. PMC: 2895108. DOI: 10.1073/pnas.1001261107. View

11.

Yilmaz O, Yao L, Maeda K, Rose T, Lewis E, Duman M . ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis. Cell Microbiol. 2007; 10(4):863-75. PMC: 2637656. DOI: 10.1111/j.1462-5822.2007.01089.x. View

12.

Yang Y, Weng W, Peng J, Hong L, Yang L, Toiyama Y . Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-κB, and Up-regulating Expression of MicroRNA-21. Gastroenterology. 2016; 152(4):851-866.e24. PMC: 5555435. DOI: 10.1053/j.gastro.2016.11.018. View

13.

Janssens S, Beyaert R . A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem Sci. 2002; 27(9):474-82. DOI: 10.1016/s0968-0004(02)02145-x. View

14.

Wei M, Shi S, Liang C, Meng Q, Hua J, Zhang Y . The microbiota and microbiome in pancreatic cancer: more influential than expected. Mol Cancer. 2019; 18(1):97. PMC: 6526613. DOI: 10.1186/s12943-019-1008-0. View

15.

Lee J, Paull T . Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science. 2004; 304(5667):93-6. DOI: 10.1126/science.1091496. View

16.

Whitmore S, Lamont R . Oral bacteria and cancer. PLoS Pathog. 2014; 10(3):e1003933. PMC: 3968118. DOI: 10.1371/journal.ppat.1003933. View

17.

Fan X, Alekseyenko A, Wu J, Peters B, Jacobs E, Gapstur S . Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut. 2016; 67(1):120-127. PMC: 5607064. DOI: 10.1136/gutjnl-2016-312580. View

18.

Paturel L, Casalta J, Habib G, Nezri M, Raoult D . Actinobacillus actinomycetemcomitans endocarditis. Clin Microbiol Infect. 2004; 10(2):98-118. DOI: 10.1111/j.1469-0691.2004.00794.x. View

19.

Jazayeri A, Falck J, Lukas C, Bartek J, Smith G, Lukas J . ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol. 2005; 8(1):37-45. DOI: 10.1038/ncb1337. View

20.

Siegel R, Miller K, Jemal A . Cancer statistics, 2019. CA Cancer J Clin. 2019; 69(1):7-34. DOI: 10.3322/caac.21551. View