Association Between Health Related Quality of Life and Progression of Chronic Kidney Disease

Overview

Journal Sci Rep

Specialty Science

Date 2019 Dec 22

PMID 31863079

Citations 20

Authors

Tae Ryom Oh

Hong Sang Choi

Chang Seong Kim

Eun Hui Bae

Yun Kyu Oh

Yong-Soo Kim

Kyu Hun Choi

Soo Wan Kim

Seong Kwon Ma

Affiliations

Soon will be listed here.

Abstract

The impact of health-related quality of life (HRQOL) on outcomes remains unclear in chronic kidney disease (CKD) patients despite its importance in socioeconomic aspects and individual health. We aim to identify the relationship between HRQOL and progression of CKD in pre-dialysis patients. A total 1622 patients with CKD were analyzed in the KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease, a prospective cohort study. CKD progression was defined as one or more of the following: initiation of dialysis or transplantation, a two-fold increase in baseline serum creatinine levels, or a 50% decline in the estimated glomerular filtration rate during the follow-up period. The group with CKD progression had lower scores of HRQOL than the group without CKD progression. A fully adjusted Cox proportional hazard ratio model showed that each low baseline physical and mental component summary score was associated with a higher risk of CKD progression. In Kaplan-Meier survival analysis using propensity score matched data, only low physical component summary scores showed statistical significance with CKD progression. Our study highlights low physical component summary score for an important prognostic factor of CKD progression. Risk-modification interventions for high-risk patients may provide benefits to individuals.

Citing Articles

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The association between socioeconomic status and health-related quality of life among young and middle-aged maintenance hemodialysis patients: multiple mediation modeling.

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