New Spotted Fever Group Isolate, Identified by Sequence Analysis of Conserved Genomic Regions

Overview

Journal Pathogens

Date 2019 Dec 22

PMID 31861899

Citations 6

Authors

Dar Klein

Adi Beth-Din

Regev Cohen

Shirley Lazar

Itai Glinert

Hiba Zayyad

Yafit Atiya-Nasagi

Affiliations

Soon will be listed here.

Abstract

The clinical features of spotted fever group (SFG) induced disease range from a mild to severe illness. The clinical complexity is even greater due to the fact that the disease can be caused by different species with varying degrees of virulence. Current knowledge asserts that the Israeli SFG (ISF) strain is the only human pathogenic SFG member in Israel. Current diagnostic procedures distinguish between SFG and the typhus group rickettsiosis, assuming all SFG-positive clinical samples positive for ISF. Molecular studies on questing ticks over the past decade have uncovered the existence of other SFG strains besides ISF in Israel and the region. This study describes the first documented analysis of SFG-positive samples from Israeli patients with the goal of distinguishing between ISF and non-ISF SFG strains. We managed to identify a new isolate from three independent clinical samples in Israel which was shown to be an as-yet unknown SFG member, showing no absolute identity with any known species present in the NCBI database.

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