Nanomaterials As Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2019 Dec 22

PMID 31861725

Citations 16

Authors

Marco Cordani

Raffaele Strippoli

Alvaro Somoza

Affiliations

Soon will be listed here.

Abstract

Epithelial-mesenchymal transition (EMT) has emerged as a key regulator of cell invasion and metastasis in cancers. Besides the acquisition of migratory/invasive abilities, the EMT process is tightly connected with the generation of cancer stem cells (CSCs), thus contributing to chemoresistance. However, although EMT represents a relevant therapeutic target for cancer treatment, its application in the clinic is still limited due to various reasons, including tumor-stage heterogeneity, molecular-cellular target specificity, and appropriate drug delivery. Concerning this last point, different nanomaterials may be used to counteract EMT induction, providing novel therapeutic tools against many different cancers. In this review, (1) we discuss the application of various nanomaterials for EMT-based therapies in cancer, (2) we summarize the therapeutic relevance of some of the proposed EMT targets, and (3) we review the potential benefits and weaknesses of each approach.

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References

Pan Y, Zhang J, Fu H, Shen L . miR-144 functions as a tumor suppressor in breast cancer through inhibiting ZEB1/2-mediated epithelial mesenchymal transition process. Onco Targets Ther. 2016; 9:6247-6255. PMC: 5067005. DOI: 10.2147/OTT.S103650. View

Guo Z, Li W, Yuan Y, Zheng K, Tang Y, Ma K . Improvement of chemosensitivity and inhibition of migration via targeting tumor epithelial-to-mesenchymal transition cells by ADH-1-modified liposomes. Drug Deliv. 2017; 25(1):112-121. PMC: 6058515. DOI: 10.1080/10717544.2017.1417511. View

Wang P, Voronkova M, Luanpitpong S, He X, Riedel H, Dinu C . Induction of Slug by Chronic Exposure to Single-Walled Carbon Nanotubes Promotes Tumor Formation and Metastasis. Chem Res Toxicol. 2017; 30(7):1396-1405. PMC: 5774007. DOI: 10.1021/acs.chemrestox.7b00049. View

Kumari M, Ray L, Purohit M, Patnaik S, Pant A, Shukla Y . Curcumin loading potentiates the chemotherapeutic efficacy of selenium nanoparticles in HCT116 cells and Ehrlich's ascites carcinoma bearing mice. Eur J Pharm Biopharm. 2017; 117:346-362. DOI: 10.1016/j.ejpb.2017.05.003. View

Guo C, You D, Li H, Tuo X, Liu Z . Spherical silica nanoparticles promote malignant transformation of BEAS-2B cells by stromal cell-derived factor-1α (SDF-1α). J Int Med Res. 2019; 47(3):1264-1278. PMC: 6421376. DOI: 10.1177/0300060518814333. View

Saitoh M, Endo K, Furuya S, Minami M, Fukasawa A, Imamura T . STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression. Oncogene. 2015; 35(8):1049-57. DOI: 10.1038/onc.2015.161. View

Wang X, Sun B, Liu S, Xia T . Structure Activity Relationships of Engineered Nanomaterials in inducing NLRP3 Inflammasome Activation and Chronic Lung Fibrosis. NanoImpact. 2017; 6:99-108. PMC: 5415341. DOI: 10.1016/j.impact.2016.08.002. View

Wang L, Luanpitpong S, Castranova V, Tse W, Lu Y, Pongrakhananon V . Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells. Nano Lett. 2011; 11(7):2796-803. PMC: 3135732. DOI: 10.1021/nl2011214. View

Stanisavljevic J, Porta-de-la-Riva M, Batlle R, Garcia de Herreros A, Baulida J . The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription. J Cell Sci. 2012; 124(Pt 24):4161-71. DOI: 10.1242/jcs.078824. View

10.

Peng F, Tee J, Setyawati M, Ding X, Yeo H, Tan Y . Inorganic Nanomaterials as Highly Efficient Inhibitors of Cellular Hepatic Fibrosis. ACS Appl Mater Interfaces. 2018; 10(38):31938-31946. DOI: 10.1021/acsami.8b10527. View

11.

Jin H, Zhao Y, Zhang S, Yang J, Zhang X, Ma S . Hyperthermia inhibits the motility of gemcitabine-resistant pancreatic cancer PANC-1 cells through the inhibition of epithelial-mesenchymal transition. Mol Med Rep. 2018; 17(5):7274-7280. DOI: 10.3892/mmr.2018.8763. View

12.

Daman Z, Faghihi H, Montazeri H . Salinomycin nanoparticles interfere with tumor cell growth and the tumor microenvironment in an orthotopic model of pancreatic cancer. Drug Dev Ind Pharm. 2018; 44(9):1434-1442. DOI: 10.1080/03639045.2018.1459674. View

13.

Hadinoto K, Sundaresan A, Cheow W . Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review. Eur J Pharm Biopharm. 2013; 85(3 Pt A):427-43. DOI: 10.1016/j.ejpb.2013.07.002. View

14.

Tang S, Yin Q, Su J, Sun H, Meng Q, Chen Y . Inhibition of metastasis and growth of breast cancer by pH-sensitive poly (β-amino ester) nanoparticles co-delivering two siRNA and paclitaxel. Biomaterials. 2015; 48:1-15. DOI: 10.1016/j.biomaterials.2015.01.049. View

15.

Lu H, Meng X, Yang C . Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate. Drug Metab Dispos. 2003; 31(5):572-9. DOI: 10.1124/dmd.31.5.572. View

16.

Williams K, Veenhuizen P, de la Torre B, Eritja R, Dekker C . Nanotechnology: carbon nanotubes with DNA recognition. Nature. 2002; 420(6917):761. DOI: 10.1038/420761a. View

17.

Shen J, Sun H, Xu P, Yin Q, Zhang Z, Wang S . Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles. Biomaterials. 2012; 34(5):1581-90. DOI: 10.1016/j.biomaterials.2012.10.057. View

18.

Conde J, Doria G, Baptista P . Noble metal nanoparticles applications in cancer. J Drug Deliv. 2011; 2012:751075. PMC: 3189598. DOI: 10.1155/2012/751075. View

19.

Gliga A, Di Bucchianico S, Lindvall J, Fadeel B, Karlsson H . RNA-sequencing reveals long-term effects of silver nanoparticles on human lung cells. Sci Rep. 2018; 8(1):6668. PMC: 5923294. DOI: 10.1038/s41598-018-25085-5. View

20.

Bianchi A, Gervasi M, Bakin A . Role of β5-integrin in epithelial-mesenchymal transition in response to TGF-β. Cell Cycle. 2010; 9(8):1647-59. DOI: 10.4161/cc.9.8.11517. View