Exosomal MicroRNA-155 Inhibits Enterovirus A71 Infection by Targeting PICALM

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2019 Dec 20

PMID 31853228

Citations 15

Authors

Jing Wu

Jiaqi Gu

Li Shen

Daihua Fang

Xinran Zou

Yuwen Cao

Shengjun Wang

Lingxiang Mao

Affiliations

Soon will be listed here.

Abstract

Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease (HFMD) that is associated with neurological complications. Researchers have shown that exosomes containing host cellular microRNA (miRNA) can modulate the recipient's cellular response during viral infection. However, it is unclear how exosomal miRNAs regulate this response during EV-A71 infection. In this study, we used an exosomal miRNA chip to show that microRNA-155 (miR-155) was markedly enriched in exosomes after EV-A71 infection. Moreover, exosomal miR-155 efficaciously inhibited EV-A71 infection by targeting phosphatidylinositol clathrin assembly protein (PICALM) in recipient cells. Importantly, we confirmed that exosomal miR-155 reduced EV-A71 infection severity . Additionally, miR-155 levels in throat swabs from EV-A71-infected patients were higher than in those from healthy individuals. Collectively, our findings provide evidence that exosomal miR-155 plays a role in host-pathogen interactions by mediating EV-A71 infection via the repression of PICALM; these results provide insights into the regulatory mechanisms of viral infection.

Citing Articles

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Miao Q, Li S, Lyu W, Zhang J, Han Y Drug Des Devel Ther. 2025; 19:457-469.

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An HIV-1 CRISPR-Cas9 membrane trafficking screen reveals a role for PICALM intersecting endolysosomes and immunity.

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Emerging roles of exosomes in oral diseases progression.

Wang J, Jing J, Zhou C, Fan Y Int J Oral Sci. 2024; 16(1):4.

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infection upregulates and engages host macrophage Argonaute 1, and system-wide proteomics reveals Argonaute 1-dependent host response.

Moradimotlagh A, Chen S, Koohbor S, Moon K, Foster L, Reiner N Front Immunol. 2023; 14:1287539.

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