Integral Lipids of Human Hair

Overview

Journal Lipids

Specialty Biochemistry

Date 1988 Sep 1

PMID 3185123

Citations 6

Authors

P W Wertz

D T Downing

Affiliations

Soon will be listed here.

Abstract

It has long been recognized that hair is coated with nonpolar lipids originating in the sebaceous glands, and recently it has been shown that hair also contains cholesterol sulfate and small amounts of ceramides, similar to those found in the keratinized portion of the epidermis. In the present study, it is demonstrated that significant amounts of several additional lipids are tightly associated with hair in such a way as to be highly resistant to solvent extraction. These integral hair lipids included cholesterol sulfate (3.3 mg/g of extracted hair), cholesterol (0.6 mg/g), fatty alcohols (0.2 mg/g) and free fatty acids (4.3 mg/g). The principal fatty acid, comprising 40% of the total fatty acids, was identified as 18-methyl-eicosanoic acid by cochromatography with authentic standard on gas-liquid chromatography (GLC) and by mass spectrometry (MS).

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The ethnic differences of the damage of hair and integral hair lipid after ultra violet radiation.

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References

Zuneda M, Guillenea J, Dominguez J, Prado A, Goni F . Lipid composition and protoplast-forming capacity of Streptomyces antibioticus. Lipids. 1984; 19(3):223-8. DOI: 10.1007/BF02534801. View

Song Y, Sawa T, Tsuchiya M, Horiuchi Y, Kondo S, Hamada M . The screening of beta-lactamase inhibitors: inhibition by fatty acids produced by bacteria. J Antibiot (Tokyo). 1981; 34(8):980-3. DOI: 10.7164/antibiotics.34.980. View

Wertz P, Downing D . Covalently bound omega-hydroxyacylsphingosine in the stratum corneum. Biochim Biophys Acta. 1987; 917(1):108-11. DOI: 10.1016/0005-2760(87)90290-6. View

Wertz P, Downing D . Covalent attachment of omega-hydroxyacid derivatives to epidermal macromolecules: a preliminary characterization. Biochem Biophys Res Commun. 1986; 137(3):992-7. DOI: 10.1016/0006-291x(86)90323-2. View

SWARTZENDRUBER D, Wertz P, Madison K, Downing D . Evidence that the corneocyte has a chemically bound lipid envelope. J Invest Dermatol. 1987; 88(6):709-13. DOI: 10.1111/1523-1747.ep12470383. View

Nicolaides N, Fu H, Ansari M, Rice G . The fatty acids of wax esters and sterol esters from vernix caseosa and from human skin surface lipid. Lipids. 1972; 7(8):506-17. DOI: 10.1007/BF02533016. View

ROGERS G . Electron microscope studies of hair and wool. Ann N Y Acad Sci. 1959; 83:378-99. DOI: 10.1111/j.1749-6632.1960.tb40914.x. View

Nicolaides N, Fu H, Rice G . The skin surface lipids of man compared with those of eighteen species of animals. J Invest Dermatol. 1968; 51(2):83-9. DOI: 10.1038/jid.1968.96. View

Nicolaides N, Apon J . Further studies of the saturated methyl branched fatty acids of vernix caseosa lipid. Lipids. 1976; 11(11):781-90. DOI: 10.1007/BF02533404. View

10.

Wix M, Wertz P, Downing D . Polar lipid composition of mammalian hair. Comp Biochem Physiol B. 1987; 86(4):671-3. DOI: 10.1016/0305-0491(87)90208-2. View

11.

Downing D . Photodensitometry in the thin-layer chromatographic analysis of neutral lipids. J Chromatogr. 1968; 38(1):91-9. DOI: 10.1016/0021-9673(68)85011-3. View

12.

BIRBECK M, MERCER E . Cell membranes and morphogenesis. Nature. 1956; 178(4540):985-6. DOI: 10.1038/178985b0. View

13.

Kaneda T, Smith E . Relationship of primer specificity of fatty acid de novo synthetase to fatty acid composition in 10 species of bacteria and yeasts. Can J Microbiol. 1980; 26(8):893-8. DOI: 10.1139/m80-155. View

14.

PARAKKAL P, MATOLTSY A . A STUDY OF THE DIFFERENTIATION PRODUCTS OF THE HAIR FOLLICLE CELLS WITH THE ELECTRON MICROSCOPE. J Invest Dermatol. 1964; 42:23-34. View