Peripheral Giant Cell Granuloma Associated with a Dental Implant

Overview

Journal BMC Oral Health

Publisher Biomed Central

Specialty Dentistry

Date 2019 Dec 18

PMID 31842866

Citations 5

Authors

Rafaela Carrico Porto Baesso

Maria Carolina de Lima Jacy Monteiro Barki

Rebeca de Souza Azevedo

Karla Bianca Fernandes da Costa Fontes

Debora Lima Pereira

Renata Tucci

Fabio Ramoa Pires

Bruna Lavinas Sayed Picciani

Affiliations

Soon will be listed here.

Abstract

Background: Peripheral giant cell granuloma (PGCG) is an uncommon pathology that affects gingival or alveolar mucosa. Although PGCG can be associated with dental implants, little is known about this lesion and implant osseointegration as well as its etiopathogenesis and the treatments available. This study sought to report a rare case of PGCG associated with dental implant, emphasizing its clinical and histopathological aspects.

Case Presentation: A 53-year-old man had an exophytic, reddish lesion, around a crown attached to a dental implant located in the left mandible. Radiographically, there was bone loss around the implant. After excisional biopsy, histological examination revealed a submucosal proliferation of multinucleated giant cells rendering the diagnosis of peripheral giant cell granuloma. Patient has been under follow-up for 6 months with no recurrence.

Conclusions: Peri-implant lesions must be completely removed to prevent recurrence of PGCG and implant failure, even in cases suspected to be reactive. Besides, histological examination must be performed on all peri-implant reactions to achieve the appropriate diagnosis and, consequently, the best treatment and follow up.

Citing Articles

Relevance and Timing of Implant-Driven Rehabilitation in Central Giant Cell Granuloma Cases-A Scoping Review.

Tatiana R, Thomas R, Olivier L, Gilbert N, Naji K, Etienne O Clin Exp Dent Res. 2025; 11(1):e70085.

PMID: 39940092 PMC: 11821547. DOI: 10.1002/cre2.70085.

Peripheral Giant Cell Granuloma - A Case Report of a 9-Year-Old Male Child.

Sharma M, Sarma M, Choudhury D, Rao S, Santosh B, Debnath A J Pharm Bioallied Sci. 2024; 16(Suppl 3):S2968-S2971.

PMID: 39346253 PMC: 11426918. DOI: 10.4103/jpbs.jpbs_88_24.

Oral Pyogenic Granuloma: A Narrative Review.

Lomeli Martinez S, Carrillo Contreras N, Gomez Sandoval J, Zepeda Nuno J, Gomez Mireles J, Varela Hernandez J Int J Mol Sci. 2023; 24(23).

PMID: 38069207 PMC: 10706684. DOI: 10.3390/ijms242316885.

Peripheral giant cell granuloma of maxilla.

Sharma N, Rana S, Jetley S J Indian Soc Periodontol. 2022; 26(1):75-78.

PMID: 35136321 PMC: 8796777. DOI: 10.4103/jisp.jisp_624_20.

An analysis of the prevalence of peripheral giant cell granuloma and pyogenic granuloma in relation to a dental implant.

Roman-Quesada N, Gonzalez-Navarro B, Izquierdo-Gomez K, Jane-Salas E, Mari-Roig A, Estrugo-Devesa A BMC Oral Health. 2021; 21(1):204.

PMID: 33892689 PMC: 8067650. DOI: 10.1186/s12903-021-01566-4.

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