Transcription Closed and Open Complex Formation Coordinate Expression of Genes with a Shared Promoter Region

Overview

Journal J R Soc Interface

Specialties Biology
Biomedical Engineering
Biophysics

Date 2019 Dec 12

PMID 31822223

Citations 1

Authors

Antti Hakkinen

Samuel M D Oliveira

Ramakanth Neeli-Venkata

Andre S Ribeiro

Affiliations

Soon will be listed here.

Abstract

Many genes are spaced closely, allowing coordination without explicit control through shared regulatory elements and molecular interactions. We study the dynamics of a stochastic model of a gene-pair in a head-to-head configuration, sharing promoter elements, which accounts for the rate-limiting steps in transcription initiation. We find that only in specific regions of the parameter space of the rate-limiting steps is orderly coexpression exhibited, suggesting that successful cooperation between closely spaced genes requires the coevolution of compatible rate-limiting step configuration. The model predictions are validated using single-cell, single-RNA measurements of the dynamics of pairs of genes sharing promoter elements. Our results suggest that, in , the kinetics of the rate-limiting steps in active transcription can play a central role in shaping the dynamics of gene-pairs sharing promoter elements.

Citing Articles

Analytical kinetic model of native tandem promoters in E. coli.

Chauhan V, Bahrudeen M, Palma C, Baptista I, Almeida B, Dash S PLoS Comput Biol. 2022; 18(1):e1009824.

PMID: 35100257 PMC: 8830795. DOI: 10.1371/journal.pcbi.1009824.

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