Accentuated Osseointegration in Osteogenic Nanofibrous Coated Titanium Implants

Overview

Journal Sci Rep

Specialty Science

Date 2019 Dec 11

PMID 31819073

Citations 7

Authors

Siddhartha Das

Kanchan Dholam

Sandeep Gurav

Kiran Bendale

Arvind Ingle

Bhabani Mohanty

Pradip Chaudhari

Jayesh R Bellare

Affiliations

Soon will be listed here.

Abstract

Anchoring of endosseous implant through osseointegration continues to be an important clinical need. Here, we describe the development of superior endosseous implant demonstrating enhance osseointegration, achieved through surface modification via coating of osteogenic nanofibres. The randomized bio-composite osteogenic nanofibres incorporating polycaprolactone, gelatin, hydroxyapatite, dexamethasone, beta-glycerophosphate and ascorbic acid were electrospun on titanium implants mimicking bone extracellular matrix and subsequently induced osteogenesis by targeting undifferentiated mesenchymal stem cells present in the peri-implant niche to regenerate osseous tissue. In proof-of-concept experiment on rabbit study models (n = 6), micro-computed tomography (Micro-CT), histomorphometric analysis and biomechanical testing in relation to our novel osteogenic nanofibrous coated implants showed improved results when compared to uncoated controls. Further, no pathological changes were detected during gross examination and necropsy on peri-implant osseous tissues regenerated in response to such coated implants. The findings of the present study confirm that osteogenic nanofibrous coating significantly increases the magnitude of osteogenesis in the peri-implant zone and favours the dynamics of osseointegration.

Citing Articles

Buccal Mesenchymal Stromal Cells as a Source of Osseointegration of Titanium Implants.

Surovtseva M, Kim I, Bondarenko N, Ostapets S, Drovosekov M, Kosareva O Bull Exp Biol Med. 2024; 176(5):620-625.

PMID: 38733480 DOI: 10.1007/s10517-024-06080-5.

Kappa-carrageenan-Functionalization of octacalcium phosphate-coated titanium Discs enhances pre-osteoblast behavior and osteogenic differentiation.

Cao W, Jin J, Wu G, Bravenboer N, Helder M, Schulten E Front Bioeng Biotechnol. 2022; 10:1011853.

PMID: 36338134 PMC: 9632979. DOI: 10.3389/fbioe.2022.1011853.

Micro X-ray Spectral Analysis and Comprehensive In Vivo Study of Modified Titanium Implants.

Eshkulov U, Ivanov S, Tarbokov V, Volkov A, Dymnikov A, Shaikhaliev A Bull Exp Biol Med. 2022; 173(4):500-504.

PMID: 36063299 DOI: 10.1007/s10517-022-05570-8.

X-ray computed microtomography datasets for osteogenic nanofibrous coated titanium implants.

Das S, Dholam K, Gurav S, Bendale K, Ingle A, Mohanty B Sci Data. 2022; 9(1):348.

PMID: 35717538 PMC: 9206670. DOI: 10.1038/s41597-022-01400-8.

Semaphorin3A promotes osseointegration of titanium implants in osteoporotic rabbits.

Song A, Jiang F, Wang Y, Wang M, Wu Y, Zheng Y Clin Oral Investig. 2021; 26(1):969-979.

PMID: 34363102 DOI: 10.1007/s00784-021-04081-6.

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