Association of Bone Mineral Density with Lung Function in a Chinese General Population: the Xinxiang Rural Cohort Study

Overview

Journal BMC Pulm Med

Publisher Biomed Central

Specialty Pulmonary Medicine

Date 2019 Dec 11

PMID 31818275

Citations 10

Authors

Xiang Zeng

Dongling Liu

Xiangmei Zhao

Ling Chao

Yuchun Li

Huijun Li

Wen Li

Lihui Gui

Weidong Wu

Affiliations

Soon will be listed here.

Abstract

Background: Bone mineral density (BMD) has been positively associated with lung function in patients diagnosed with respiratory diseases such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis. However, the relationship between BMD and lung function is inconsistent in the general population.

Methods: To investigate the association between BMD and lung function in a Chinese general population, a total of 1024 adults aged 40-70 years old from Qiliying (an industrial polluted exposure area) and Langgongmiao (the reference area with non-industrial pollution) were recruited and underwent BMD and spirometry tests.

Results: Both BMD and lung function levels were lower in the exposed area compared to the reference area. In addition, BMD and lung function levels were also lower in females compared to males. Both Spearman and partial correlation analyses showed that BMD was positively correlated with FVC and FEV. After adjusting linear regression analyses for potential confounding factors, every 0.1 g/cm drop in BMD was associated with 53.0 mL decrease in FVC and 33.5 mL decrease in FEV.

Conclusions: A reduction of BMD is associated with lower lung function in a general population from China.

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References

Choi J, Pai S . Association between respiratory function and osteoporosis in pre- and postmenopausal women. Maturitas. 2004; 48(3):253-8. DOI: 10.1016/j.maturitas.2003.12.013. View

Lee I, Leem A, Lee S, Rhee Y, Ha Y, Kim Y . Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey. Korean J Intern Med. 2016; 31(5):899-909. PMC: 5016283. DOI: 10.3904/kjim.2015.127. View

Choudhury G, Rabinovich R, MacNee W . Comorbidities and systemic effects of chronic obstructive pulmonary disease. Clin Chest Med. 2014; 35(1):101-30. DOI: 10.1016/j.ccm.2013.10.007. View

Zeng X, Xu X, Zhang Y, Li W, Huo X . Chest circumference and birth weight are good predictors of lung function in preschool children from an e-waste recycling area. Environ Sci Pollut Res Int. 2017; 24(28):22613-22621. DOI: 10.1007/s11356-017-9885-5. View

Decramer M, Janssens W . Chronic obstructive pulmonary disease and comorbidities. Lancet Respir Med. 2013; 1(1):73-83. DOI: 10.1016/S2213-2600(12)70060-7. View

Cho Y, Choi S, Kim K, Lee G, Park S . Association between alcohol consumption and bone mineral density in elderly Korean men and women. Arch Osteoporos. 2018; 13(1):46. DOI: 10.1007/s11657-018-0462-4. View

Inoue D, Watanabe R, Okazaki R . COPD and osteoporosis: links, risks, and treatment challenges. Int J Chron Obstruct Pulmon Dis. 2016; 11:637-48. PMC: 4820217. DOI: 10.2147/COPD.S79638. View

Conway S . Osteoporosis is cystic fibrosis. J Cyst Fibros. 2004; 2(4):161-2. DOI: 10.1016/S1569-1993(03)00086-9. View

Law M, Cheng R, Hackshaw A, Allaway S, Hale A . Cigarette smoking, sex hormones and bone density in women. Eur J Epidemiol. 1997; 13(5):553-8. DOI: 10.1023/a:1007389712487. View

10.

Putman M, Baker J, Uluer A, Herlyn K, Lapey A, Sicilian L . Trends in bone mineral density in young adults with cystic fibrosis over a 15 year period. J Cyst Fibros. 2015; 14(4):526-32. PMC: 4485936. DOI: 10.1016/j.jcf.2015.01.011. View

11.

Romme E, McAllister D, Murchison J, van Beek E, Petrides G, Price C . Associations between COPD related manifestations: a cross-sectional study. Respir Res. 2013; 14:129. PMC: 3840707. DOI: 10.1186/1465-9921-14-129. View

12.

Franco C, Paz-Filho G, Gomes P, Nascimento V, Kulak C, Boguszewski C . Chronic obstructive pulmonary disease is associated with osteoporosis and low levels of vitamin D. Osteoporos Int. 2009; 20(11):1881-7. DOI: 10.1007/s00198-009-0890-5. View

13.

Liu X, Wu W, Mao Z, Huo W, Tu R, Qian X . Prevalence and influencing factors of overweight and obesity in a Chinese rural population: the Henan Rural Cohort Study. Sci Rep. 2018; 8(1):13101. PMC: 6117281. DOI: 10.1038/s41598-018-31336-2. View

14.

Kanis J . Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int. 1994; 4(6):368-81. DOI: 10.1007/BF01622200. View

15.

Zhao J, Zeng X, Wang J, Liu L . Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. JAMA. 2017; 318(24):2466-2482. PMC: 5820727. DOI: 10.1001/jama.2017.19344. View

16.

Jeon Y, Shin M, Kim W, Kim S, Kim B, Kim S . The relationship between pulmonary function and bone mineral density in healthy nonsmoking women: the Korean National Health and Nutrition Examination Survey (KNHANES) 2010. Osteoporos Int. 2014; 25(5):1571-6. DOI: 10.1007/s00198-014-2627-3. View

17.

Liu W, Kuo H, Liao T, Chiang L, Chen L, Hsu M . Low bone mineral density in COPD patients with osteoporosis is related to low daily physical activity and high COPD assessment test scores. Int J Chron Obstruct Pulmon Dis. 2015; 10:1737-44. PMC: 4562728. DOI: 10.2147/COPD.S87110. View

18.

Egger P, Duggleby S, Hobbs R, Fall C, Cooper C . Cigarette smoking and bone mineral density in the elderly. J Epidemiol Community Health. 1996; 50(1):47-50. PMC: 1060203. DOI: 10.1136/jech.50.1.47. View

19.

Sermet-Gaudelus I, Souberbielle J, Ruiz J, Vrielynck S, Heuillon B, Azhar I . Low bone mineral density in young children with cystic fibrosis. Am J Respir Crit Care Med. 2007; 175(9):951-7. DOI: 10.1164/rccm.200606-776OC. View

20.

Vrieze A, de Greef M, Wijkstra P, Wykstra P, Wempe J . Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass. Osteoporos Int. 2007; 18(9):1197-202. DOI: 10.1007/s00198-007-0355-7. View