Protection Against Absolute-ethanol-induced Gastric Antral and Corpus Mucosal Injury. A Gross and Histologic Study

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 1988 Nov 1

PMID 3180978

Citations 10

Authors

S K Lo

F W Leung

P H Guth

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to systematically assess 100% ethanol-induced gross and histologic injury of the antral and the corpus mucosa of the rat stomach and the effect of two protective agents, a prostaglandin analog and meciadanol (a flavenoid) on this injury. The gross antral injury was much more subtle than the corpus injury. Therefore, different scoring criteria were developed for the antrum. Surprisingly, however, the extent and severity of histologic injury was similar in both areas. Pretreatment with either meciadanol or 16,16-dimethyl prostaglandin E2 significantly protected against this injury in the antrum as well as in the corpus.

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References

Shirazi S, Mueller T, Hardy B . Canine gastric acid secretion and blood flow measurement in hemorrhagic shock. Gastroenterology. 1977; 73(1):75-8. View

Lacy E, Ito S . Microscopic analysis of ethanol damage to rat gastric mucosa after treatment with a prostaglandin. Gastroenterology. 1982; 83(3):619-25. View

Ito S, Lacy E . Morphology of rat gastric mucosal damage, defense, and restitution in the presence of luminal ethanol. Gastroenterology. 1985; 88(1 Pt 2):250-60. DOI: 10.1016/s0016-5085(85)80178-5. View

Leung F, Itoh M, Hirabayashi K, Guth P . Role of blood flow in gastric and duodenal mucosal injury in the rat. Gastroenterology. 1985; 88(1 Pt 2):281-9. DOI: 10.1016/s0016-5085(85)80181-5. View

Hollander D, Tarnawski A, Gergely H, Zipser R . Sucralfate protection of the gastric mucosa against ethanol-induced injury: a prostaglandin-mediated process?. Scand J Gastroenterol Suppl. 1984; 101:97-102. View

Guth P, Paulsen G, Nagata H . Histologic and microcirculatory changes in alcohol-induced gastric lesions in the rat: effect of prostaglandin cytoprotection. Gastroenterology. 1984; 87(5):1083-90. View

Itoh M, Paulsen G, Guth P . Hemorrhagic shock and acid gastric injury in the rat. Comparison of gross and histologic findings. Gastroenterology. 1986; 90(5 Pt 1):1103-10. DOI: 10.1016/0016-5085(86)90374-4. View

Ohno T, Ohtsuki H, Okabe S . Effects of 16,16-dimethyl prostaglandin E2 on ethanol-induced and aspirin-induced gastric damage in the rat. Scanning electron microscopic study. Gastroenterology. 1985; 88(1 Pt 2):353-61. DOI: 10.1016/s0016-5085(85)80189-x. View

Whittle B, Steel G . Evaluation of the protection of rat gastric mucosa by a prostaglandin analogue using cellular enzyme marker and histologic techniques. Gastroenterology. 1985; 88(1 Pt 2):315-27. DOI: 10.1016/s0016-5085(85)80186-4. View

10.

Manabe T, Suzuki T, Honjo I . Changes of upper gastrointestinal blood flow after hemorrhage in rabbits. Surgery. 1977; 81(4):446-52. View

11.

Kivilaakso E, Fromm D, Silen W . Relationship between ulceration and intramural pH of gastric mucosa during hemorrhagic shock. Surgery. 1978; 84(1):70-8. View

12.

Konturek S, Kitler M, Brzozowski T, RADECKI T . Gastric protection by meciadanol. A new synthetic flavonoid inhibiting histidine decarboxylase. Dig Dis Sci. 1986; 31(8):847-52. DOI: 10.1007/BF01296054. View

13.

Robert A, NEZAMIS J, Lancaster C, Davis J, Field S, Hanchar A . Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins. Am J Physiol. 1983; 245(1):G113-21. DOI: 10.1152/ajpgi.1983.245.1.G113. View

14.

Lacy E . Prostaglandins and histological changes in the gastric mucosa. Dig Dis Sci. 1985; 30(11 Suppl):83S-94S. DOI: 10.1007/BF01309391. View

15.

Robert A, NEZAMIS J, Lancaster C, Hanchar A . Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology. 1979; 77(3):433-43. View

16.

Tarnawski A, Hollander D, Stachura J, Krause W, Gergely H . Prostaglandin protection of the gastric mucosa against alcohol injury--a dynamic time-related process. Role of the mucosal proliferative zone. Gastroenterology. 1985; 88(1 Pt 2):334-52. DOI: 10.1016/s0016-5085(85)80188-8. View