Methane and Inflammation - A Review (Fight Fire with Fire)

Overview

Journal Intensive Care Med Exp

Specialty Critical Care

Date 2019 Dec 7

PMID 31807906

Citations 9

Authors

Marietta Zita Poles

Laszlo Juhasz

Mihaly Boros

Affiliations

Soon will be listed here.

Abstract

Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally considered to be biologically inactive. However, recent studies have provided evidence for methane bioactivity in various in vivo settings. The administration of methane either in gas form or solutions has been shown to have anti-inflammatory and neuroprotective effects in an array of experimental conditions, such as ischemia/reperfusion, endotoxemia and sepsis. It has also been demonstrated that exogenous methane influences the key regulatory mechanisms and cellular signalling pathways involved in oxidative and nitrosative stress responses. This review offers an insight into the latest findings on the multi-faceted organ protective activity of exogenous methane treatments with special emphasis on its versatile effects demonstrated in sepsis models.

Citing Articles

Methane saline suppresses ferroptosis via the Nrf2/HO-1 signaling pathway to ameliorate intestinal ischemia-reperfusion injury.

Fan Q, Chang H, Tian L, Zheng B, Liu R, Li Z Redox Rep. 2024; 29(1):2373657.

PMID: 39023011 PMC: 11259071. DOI: 10.1080/13510002.2024.2373657.

Methane-rich saline ameliorates depressive-like behaviors during chronic unpredictable mild stress (CUMS).

Nasab M, Rezvani M, Hosseini S, Mehrjerdi F Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(12):10203-10213.

PMID: 39007926 DOI: 10.1007/s00210-024-03284-4.

Impairment of Mesenteric Perfusion as a Marker of Major Bleeding in Trauma Patients.

Javor P, Donka T, Horvath T, Sandor L, Torok L, Szabo A J Clin Med. 2023; 12(10).

PMID: 37240677 PMC: 10218900. DOI: 10.3390/jcm12103571.

ROS-driven cellular methane formation: Potential implications for health sciences.

Keppler F, Ernst L, Polag D, Zhang J, Boros M Clin Transl Med. 2022; 12(7):e905.

PMID: 35839303 PMC: 9286325. DOI: 10.1002/ctm2.905.

Detection of exhaled methane levels for monitoring trauma-related haemorrhage following blunt trauma: study protocol for a prospective observational study.

Javor P, Rarosi F, Horvath T, Torok L, Varga E, Hartmann P BMJ Open. 2022; 12(7):e057872.

PMID: 35793921 PMC: 9260765. DOI: 10.1136/bmjopen-2021-057872.

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