The Emergence of Neoadjuvant Therapy in Advanced Melanoma
Overview
Affiliations
The discovery of immunotherapy and targeted therapy has introduced new and effective treatment options for advanced melanoma, providing therapeutic options where none existed before. The natural extension of these novel therapies is to identify their role in the neoadjuvant setting. Neoadjuvant therapy for advanced melanoma is still in its infancy, with a wealth of clinical trials underway. Early results are promising, allowing for management of a disease that previously had few options. We review the current literature and interim results from several ongoing investigations to understand the current state of neoadjuvant treatment options and what is to come. These studies pave the way for further advancements in melanoma therapy.
Connor C, Carr Q, Sweazy A, McMasters K, Hao H Cancers (Basel). 2025; 17(4).
PMID: 40002300 PMC: 11853469. DOI: 10.3390/cancers17040707.
Neoadjuvant Pembrolizumab and High-Dose IFNα-2b in Resectable Regionally Advanced Melanoma.
Najjar Y, McCurry D, Lin H, Lin Y, Zang Y, Davar D Clin Cancer Res. 2021; 27(15):4195-4204.
PMID: 33753453 PMC: 8338751. DOI: 10.1158/1078-0432.CCR-20-4301.
Zhang X, Liang Y Biomed Res Int. 2021; 2021:8197936.
PMID: 33506034 PMC: 7815395. DOI: 10.1155/2021/8197936.
Ceci C, Atzori M, Lacal P, Graziani G Cancers (Basel). 2020; 12(11).
PMID: 33212945 PMC: 7698460. DOI: 10.3390/cancers12113401.
Herbreteau G, Vallee A, Knol A, Theoleyre S, Quereux G, Frenard C Cancers (Basel). 2020; 12(7).
PMID: 32664549 PMC: 7409003. DOI: 10.3390/cancers12071871.