Rational Design of a Multifunctional Molecular Dye for Dual-modal NIR-II/photoacoustic Imaging and Photothermal Therapy

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2019 Dec 6

PMID 31803412

Citations 27

Authors

Ruiping Zhang

Yuling Xu

Yi Zhang

Hyeong Seok Kim

Amit Sharma

Jing Gao

Guangfu Yang

Jong Seung Kim

Yao Sun

Affiliations

Soon will be listed here.

Abstract

Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye () with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes ( NPs) (∼120 nm). studies confirmed that NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy.

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