The Effects of Zinc on Human Body, Including on Renal Failure and Renal Transplantation

Overview

Journal J Med Life

Specialty General Medicine

Date 2019 Dec 6

PMID 31803301

Citations 8

Authors

S Paun

M Tudosie

R Petris

R Macovei

Affiliations

Soon will be listed here.

Abstract

Zinc (Zn) is an important element in human body and in the last period of time there were a lot of studies regarding its importance. It is significant for the good working of many organs. A special attention was given to the importance of the serum Zn in patients with renal failure. Among the micronutrients, zinc may rank with iron with regard to its importance for public health. This article reviews some epidemiological, clinical, diagnostic and therapeutic aspects of these conditions.

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References

Oestreicher P, Cousins R . Copper and zinc absorption in the rat: mechanism of mutual antagonism. J Nutr. 1985; 115(2):159-66. DOI: 10.1093/jn/115.2.159. View

Magee A, Matrone G . Studies on growth, copper metabolism of rats fed high levels of zinc. J Nutr. 1960; 72(2):233-42. DOI: 10.1093/jn/72.2.233. View

Van Campen D . Copper interference with the intestinal absorption of zinc-65 by rats. J Nutr. 1969; 97(1):104-8. DOI: 10.1093/jn/97.1.104. View

STROMBERG H, Agren M . Topical zinc oxide treatment improves arterial and venous leg ulcers. Br J Dermatol. 1984; 111(4):461-8. DOI: 10.1111/j.1365-2133.1984.tb06610.x. View

Brown J . Zinc fume fever. Br J Radiol. 1988; 61(724):327-9. DOI: 10.1259/0007-1285-61-724-327. View

Canavese C, Mereu M, Aime S, Lazzarich E, Fenoglio R, Quaglia M . Gadolinium-associated nephrogenic systemic fibrosis: the need for nephrologists' awareness. J Nephrol. 2008; 21(3):324-36. View

Wastney M, Aamodt R, Rumble W, Henkin R . Kinetic analysis of zinc metabolism and its regulation in normal humans. Am J Physiol. 1986; 251(2 Pt 2):R398-408. DOI: 10.1152/ajpregu.1986.251.2.R398. View

Agren M, Krusell M, Franzen L . Release and absorption of zinc from zinc oxide and zinc sulfate in open wounds. Acta Derm Venereol. 1991; 71(4):330-3. View

Aggett P . Acrodermatitis enteropathica. J Inherit Metab Dis. 1983; 6 Suppl 1:39-43. DOI: 10.1007/BF01811322. View

10.

Fellah H, Feki M, Souissi M, Ghorbel H, Ben Abdallah T, Massy Z . [Oxidative stress in end stage renal disease: evidence and association with cardiovascular events in Tunisian patients]. Tunis Med. 2007; 84(11):724-9. View

11.

Porea T, Belmont J, Mahoney Jr D . Zinc-induced anemia and neutropenia in an adolescent. J Pediatr. 2000; 136(5):688-90. DOI: 10.1067/mpd.2000.103355. View

12.

Vecchio M, Navaneethan S, Johnson D, Lucisano G, Graziano G, Saglimbene V . Interventions for treating sexual dysfunction in patients with chronic kidney disease. Cochrane Database Syst Rev. 2010; (12):CD007747. DOI: 10.1002/14651858.CD007747.pub2. View

13.

Llobet J, Domingo J, Colomina M, Mayayo E, Corbella J . Subchronic oral toxicity of zinc in rats. Bull Environ Contam Toxicol. 1988; 41(1):36-43. DOI: 10.1007/BF01689056. View

14.

Mahajan S, Abraham J, Hessburg T, Prasad A, Migdal S, Briggs W . Zinc metabolism and taste acuity in renal transplant recipients. Kidney Int Suppl. 1983; 16:S310-4. View

15.

Chimienti F, Aouffen M, Favier A, Seve M . Zinc homeostasis-regulating proteins: new drug targets for triggering cell fate. Curr Drug Targets. 2003; 4(4):323-38. DOI: 10.2174/1389450033491082. View

16.

Agren M, Franzen L, Chvapil M . Effects on wound healing of zinc oxide in a hydrocolloid dressing. J Am Acad Dermatol. 1993; 29(2 Pt 1):221-7. DOI: 10.1016/0190-9622(93)70172-p. View

17.

Sandstead H . Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Am J Clin Nutr. 1995; 61(3 Suppl):621S-624S. DOI: 10.1093/ajcn/61.3.621S. View

18.

Trumbo P, Yates A, Schlicker S, Poos M . Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc. 2001; 101(3):294-301. DOI: 10.1016/S0002-8223(01)00078-5. View

19.

Eggert J, Siegler R, Edomkesmalee E . Zinc supplementation in chronic renal failure. Int J Pediatr Nephrol. 1982; 3(1):21-4. View

20.

Fischer P, Giroux A, LAbbe M . The effect of dietary zinc on intestinal copper absorption. Am J Clin Nutr. 1981; 34(9):1670-5. DOI: 10.1093/ajcn/34.9.1670. View