Self-Illuminating Agents for Deep-Tissue Optical Imaging

Overview

Journal Front Bioeng Biotechnol

Date 2019 Dec 5

PMID 31799247

Citations 7

Authors

Qing Li

Jianfeng Zeng

Qingqing Miao

Mingyuan Gao

Affiliations

Soon will be listed here.

Abstract

Optical imaging plays an indispensable role in biology and medicine attributing to its noninvasiveness, high spatiotemporal resolution, and high sensitivity. However, as a conventional optical imaging modality, fluorescence imaging confronts issues of shallow imaging depth due to the need for real-time light excitation which produces tissue autofluorescence. By contrast, self-luminescence imaging eliminates the concurrent light excitation, permitting deeper imaging depth and higher signal-to-background ratio (SBR), which has attracted growing attention. Herein, this review summarizes the progress on the development of near-infrared (NIR) emitting self-luminescence agents in deep-tissue optical imaging with highlighting the design principles including molecular- and nano-engineering approaches. Finally, it discusses current challenges and guidelines to develop more effective self-illuminating agents for biomedical diagnosis and treatment.

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