Optical Coherence Tomography Angiography Imaging in Inherited Retinal Diseases

Overview

Journal J Clin Med

Specialty General Medicine

Date 2019 Dec 5

PMID 31795241

Citations 10

Authors

Sally S Ong

Tapan P Patel

Mandeep S Singh

Affiliations

Soon will be listed here.

Abstract

Optical coherence tomography angiography (OCTA) is a novel, noninvasive imaging modality that allows depth-resolved imaging of the microvasculature in the retina and the choroid. It is a powerful research tool to study the pathobiology of retinal diseases, including inherited retinal dystrophies. In this review, we provide an overview of the evolution of OCTA technology, compare the specifications of various OCTA devices, and summarize key findings from published OCTA studies in inherited retinal dystrophies including retinitis pigmentosa, Stargardt disease, Best vitelliform macular dystrophy, and choroideremia. OCTA imaging has provided new data on characteristics of these conditions and has contributed to a deeper understanding of inherited retinal disease.

Citing Articles

Advancing Insights into Pediatric Macular Diseases: A Comprehensive Review.

Ambrosio L, Perepelkina T, Elhusseiny A, Fulton A, Gonzalez Monroy J J Clin Med. 2025; 14(2).

PMID: 39860622 PMC: 11765775. DOI: 10.3390/jcm14020614.

Utility of multimodal imaging in the clinical diagnosis of inherited retinal degenerations.

Lee B, Sun C, Ong C, Jain K, Tan T, Chan C Taiwan J Ophthalmol. 2025; 14(4):486-496.

PMID: 39803408 PMC: 11717338. DOI: 10.4103/tjo.TJO-D-24-00066.

Recent Progress in Photoreceptor Cell-Based Therapy for Degenerative Retinal Disease.

Klymenko V, Gonzalez Martinez O, Zarbin M Stem Cells Transl Med. 2024; 13(4):332-345.

PMID: 38417110 PMC: 11016853. DOI: 10.1093/stcltm/szae005.

Atypical Presentation and Delayed Diagnosis of Gyrate Atrophy: Case Reports of Two Siblings.

Ceran T, Gediz B, Sonmez K Beyoglu Eye J. 2023; 8(4):301-307.

PMID: 38089080 PMC: 10711583. DOI: 10.14744/bej.2023.72473.

IMI-Management and Investigation of High Myopia in Infants and Young Children.

Flitcroft I, Ainsworth J, Chia A, Cotter S, Harb E, Jin Z Invest Ophthalmol Vis Sci. 2023; 64(6):3.

PMID: 37126360 PMC: 10153576. DOI: 10.1167/iovs.64.6.3.

References

Zhang Q, Wang R, Chen C, Legarreta A, Durbin M, An L . SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF NEOVASCULAR MACULAR TELANGIECTASIA TYPE 2. Retina. 2015; 35(11):2285-99. PMC: 4623930. DOI: 10.1097/IAE.0000000000000840. View

Battaglia Parodi M, Cicinelli M, Rabiolo A, Pierro L, Gagliardi M, Bolognesi G . Vessel density analysis in patients with retinitis pigmentosa by means of optical coherence tomography angiography. Br J Ophthalmol. 2016; 101(4):428-432. DOI: 10.1136/bjophthalmol-2016-308925. View

Wang R, An L . Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo. Opt Express. 2009; 17(11):8926-40. PMC: 2714191. DOI: 10.1364/oe.17.008926. View

Kim D, Fingler J, Zawadzki R, Park S, Morse L, Schwartz D . Optical imaging of the chorioretinal vasculature in the living human eye. Proc Natl Acad Sci U S A. 2013; 110(35):14354-9. PMC: 3761584. DOI: 10.1073/pnas.1307315110. View

Mastropasqua R, Senatore A, Di Antonio L, Di Nicola M, Marchioni M, Perna F . Correlation between Choriocapillaris Density and Retinal Sensitivity in Stargardt Disease. J Clin Med. 2019; 8(9). PMC: 6780313. DOI: 10.3390/jcm8091432. View

Rezaei K, Zhang Q, Chen C, Chao J, Wang R . Retinal and choroidal vascular features in patients with retinitis pigmentosa imaged by OCT based microangiography. Graefes Arch Clin Exp Ophthalmol. 2017; 255(7):1287-1295. PMC: 11402510. DOI: 10.1007/s00417-017-3633-x. View

Westeneng-Van Haaften S, Boon C, Cremers F, Hoefsloot L, den Hollander A, Hoyng C . Clinical and genetic characteristics of late-onset Stargardt's disease. Ophthalmology. 2012; 119(6):1199-210. DOI: 10.1016/j.ophtha.2012.01.005. View

Lewis R, Shroyer N, Singh N, Allikmets R, Hutchinson A, Li Y . Genotype/Phenotype analysis of a photoreceptor-specific ATP-binding cassette transporter gene, ABCR, in Stargardt disease. Am J Hum Genet. 1999; 64(2):422-34. PMC: 1377752. DOI: 10.1086/302251. View

Battaglia Parodi M, Arrigo A, MacLaren R, Aragona E, Toto L, Mastropasqua R . VASCULAR ALTERATIONS REVEALED WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN PATIENTS WITH CHOROIDEREMIA. Retina. 2018; 39(6):1200-1205. DOI: 10.1097/IAE.0000000000002118. View

10.

Allikmets R, Singh N, Sun H, Shroyer N, Hutchinson A, Chidambaram A . A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet. 1997; 15(3):236-46. DOI: 10.1038/ng0397-236. View

11.

Mastropasqua R, Di Antonio L, Silvio Di Staso , Agnifili L, DI Gregorio A, Ciancaglini M . Optical Coherence Tomography Angiography in Retinal Vascular Diseases and Choroidal Neovascularization. J Ophthalmol. 2015; 2015:343515. PMC: 4600507. DOI: 10.1155/2015/343515. View

12.

Mastropasqua R, Toto L, Borrelli E, Di Antonio L, Mattei P, Senatore A . Optical Coherence Tomography Angiography Findings in Stargardt Disease. PLoS One. 2017; 12(2):e0170343. PMC: 5289432. DOI: 10.1371/journal.pone.0170343. View

13.

Sugahara M, Miyata M, Ishihara K, Gotoh N, Morooka S, Ogino K . Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa. Sci Rep. 2017; 7:46396. PMC: 5390317. DOI: 10.1038/srep46396. View

14.

Barton J, Stromski S . Flow measurement without phase information in optical coherence tomography images. Opt Express. 2009; 13(14):5234-9. DOI: 10.1364/opex.13.005234. View

15.

Takagi S, Hirami Y, Takahashi M, Fujihara M, Mandai M, Miyakoshi C . Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity. Acta Ophthalmol. 2018; 96(5):e636-e642. PMC: 6175316. DOI: 10.1111/aos.13680. View

16.

Jia Y, Tan O, Tokayer J, Potsaid B, Wang Y, Liu J . Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt Express. 2012; 20(4):4710-25. PMC: 3381646. DOI: 10.1364/OE.20.004710. View

17.

Jauregui R, Park K, Duong J, Mahajan V, Tsang S . Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography. Sci Rep. 2018; 8(1):13130. PMC: 6120860. DOI: 10.1038/s41598-018-31488-1. View

18.

Falavarjani K, Iafe N, Hubschman J, Tsui I, Sadda S, Sarraf D . Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion. Invest Ophthalmol Vis Sci. 2017; 58(1):30-34. DOI: 10.1167/iovs.16-20579. View

19.

Savary S, Allikmets R, Denizot F, Luciani M, Mattei M, Dean M . Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human. Genomics. 1997; 41(2):275-8. DOI: 10.1006/geno.1997.4658. View

20.

Jia Y, Bailey S, Hwang T, McClintic S, Gao S, Pennesi M . Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye. Proc Natl Acad Sci U S A. 2015; 112(18):E2395-402. PMC: 4426471. DOI: 10.1073/pnas.1500185112. View