» Articles » PMID: 31794387

Generalized Separable Nonnegative Matrix Factorization

Overview
Date 2019 Dec 4
PMID 31794387
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

Nonnegative matrix factorization (NMF) is a linear dimensionality technique for nonnegative data with applications such as image analysis, text mining, audio source separation, and hyperspectral unmixing. Given a data matrix M and a factorization rank r, NMF looks for a nonnegative matrix W with r columns and a nonnegative matrix H with r rows such that M ≈ WH. NMF is NP-hard to solve in general. However, it can be computed efficiently under the separability assumption which requires that the basis vectors appear as data points, that is, that there exists an index set K such that W = M(:,K). In this article, we generalize the separability assumption. We only require that for each rank-one factor W(:,k)H(k,:) for k=1,2,…,r, either W(:,k) = M(:,j) for some j or H(k,:) = M(i,:) for some i. We refer to the corresponding problem as generalized separable NMF (GS-NMF). We discuss some properties of GS-NMF and propose a convex optimization model which we solve using a fast gradient method. We also propose a heuristic algorithm inspired by the successive projection algorithm. To verify the effectiveness of our methods, we compare them with several state-of-the-art separable NMF and standard NMF algorithms on synthetic, document and image data sets.

Citing Articles

Identification of immune-related genes and patient selection for hepatocellular carcinoma immunotherapy.

Chen Z, Luo J, Ye Y, Dang Y Transl Cancer Res. 2023; 12(5):1210-1231.

PMID: 37304539 PMC: 10248567. DOI: 10.21037/tcr-22-2304.


A Novel Signature Based on Anoikis Associated with BCR-Free Survival for Prostate Cancer.

Yang C, Yu T, Lin Q Biochem Genet. 2023; 61(6):2496-2513.

PMID: 37118620 DOI: 10.1007/s10528-023-10387-9.


TIMEAS, a promising method for the stratification of testicular germ cell tumor patients with distinct immune microenvironment, clinical outcome and sensitivity to frontline therapies.

Meng J, Gao J, Li X, Gao R, Lu X, Zhou J Cell Oncol (Dordr). 2023; 46(3):745-759.

PMID: 36823338 DOI: 10.1007/s13402-023-00781-1.


Integrated bioinformatics analysis uncovers characteristic genes and molecular subtyping system for endometriosis.

Wang Z, Liu J, Li M, Lian L, Cui X, Ng T Front Pharmacol. 2022; 13:932526.

PMID: 36059959 PMC: 9428290. DOI: 10.3389/fphar.2022.932526.