Folic Acid Supplementation, Dietary Folate Intake and Risk of Small for Gestational Age in China

Overview

Journal Public Health Nutr

Publisher Cambridge University Press

Date 2019 Dec 3

PMID 31787119

Citations 5

Authors

Huaqi Guo

Baohong Mao

Meng Wang

Qing Liu

Liping Yang

Yahui Xie

Yanxia Wang

Xiaochun He

Hongmei Cui

Xiaojuan Lin

Ling Lv

Min Zhou

Xiaoying Xu

Jie Qiu

Yawei Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the hypothesis that folic acid supplementation and dietary folate intake before conception and during pregnancy reduce the risk of small for gestational age (SGA) and to examine the joint effect of folic acid supplementation and dietary folate intake on the risk of SGA.

Design: Participants were interviewed by trained study interviewers using a standardized and structured questionnaire. Information on birth outcomes and maternal complications was abstracted from medical records and dietary information was collected via a semi-quantitative FFQ before conception and during pregnancy.

Setting: A birth cohort data analysis using the 2010-2012 Gansu Provincial Maternity and Child Care Hospital.

Participants: Women (n 8758) and their children enrolled in the study.

Results: Folic acid supplementation was associated with a reduced risk of SGA (OR = 0·72, 95 % CI 0·60, 0·86), with the reduced risk seen mainly for SGA at ≥37 weeks of gestational age (OR = 0·70, 95 % CI 0·58, 0·85) and nulliparous SGA (OR = 0·67, 95 % CI 0·54, 0·84). There was no significant association between dietary folate intake and SGA risk.

Conclusions: Our study suggested that folic acid supplementation was associated with a reduced risk of SGA and the risk varied by preterm status and parity.

Citing Articles

Development and Testing of the Comprehensive Prenatal Care Index: Relationship With Preterm Birth and Small for Gestational Age Across Racial and Ethnic Groups.

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PMID: 39593248 PMC: 11622361. DOI: 10.1111/jmwh.13707.

Supplementation with Folic Acid or 5-Methyltetrahydrofolate and Prevention of Neural Tube Defects: An Evidence-Based Narrative Review.

Samaniego-Vaesken M, Morais-Moreno C, Carretero-Krug A, Puga A, Montero-Bravo A, Partearroyo T Nutrients. 2024; 16(18).

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Association of Folic Acid Supplementation in Early Pregnancy with Risk of Gestational Diabetes Mellitus: A Longitudinal Study.

Chen H, Hu Y, Li Y, Zhou W, Zhou N, Yang H Nutrients. 2022; 14(19).

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Relationships between Maternal Gene Polymorphisms in One Carbon Metabolism and Adverse Pregnancy Outcomes: A Prospective Mother and Child Cohort Study in China.

Wang S, Duan Y, Jiang S, Bi Y, Pang X, Liu C Nutrients. 2022; 14(10).

PMID: 35631247 PMC: 9146434. DOI: 10.3390/nu14102108.

Periconceptional Folic Acid Supplementation and Newborn Birth Weights.

Lin J, Wang C, Li S, Zhang J, Tong M, Meng W Front Pediatr. 2022; 10:844404.

PMID: 35573945 PMC: 9096220. DOI: 10.3389/fped.2022.844404.

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