Adenosine Receptor Profiling Reveals an Association Between the Presence of Spare Receptors and Cardiovascular Disorders

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Dec 1

PMID 31783510

Citations 11

Authors

Emmanuel Fenouillet

Giovanna Mottola

Nathalie Kipson

Franck Paganelli

Regis Guieu

Jean Ruf

Affiliations

Soon will be listed here.

Abstract

Adenosine and its receptors exert a potent control on the cardiovascular system. This review aims to present emerging experimental evidence supporting the existence and implication in cardiovascular disorders of specific adenosinergic pharmacological profiles, conforming to the concept of "receptor reserve", also known as "spare receptors". This kind of receptors allow agonists to achieve their maximal effect without occupying all of the relevant cell receptors. In the cardiovascular system, spare adenosine receptors appear to compensate for a low extracellular adenosine level and/or a low adenosine receptor number, such as in coronary artery disease or some kinds of neurocardiogenic syncopes. In both cases, the presence of spare receptors appears to be an attempt to overcome a weak interaction between adenosine and its receptors. The identification of adenosine spare receptors in cardiovascular disorders may be helpful for diagnostic purposes.

Citing Articles

Adenosinergic System and Neuroendocrine Syncope: What Is the Link?.

Guieu R, Fromonot J, Mottola G, Maille B, Marlinge M, Groppelli A Cells. 2023; 12(16).

PMID: 37626837 PMC: 10453095. DOI: 10.3390/cells12162027.

Adenosine, Adenosine Receptors and Neurohumoral Syncope: From Molecular Basis to Personalized Treatment.

Guieu R, Degioanni C, Fromonot J, De Maria L, Ruf J, Deharo J Biomedicines. 2022; 10(5).

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Is the Adenosine Test Obsolete in the Clinical Assessment of Syncope of Unknown Origin?.

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Expression and Gene Regulation Network of Adenosine Receptor A2B in Lung Adenocarcinoma: A Potential Diagnostic and Prognostic Biomarker.

Sui Y, Liu J, Zhang J, Zheng Z, Wang Z, Jia Z Front Mol Biosci. 2021; 8:663011.

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Adenosine Receptor Reserve and Long-Term Potentiation: Unconventional Adaptive Mechanisms in Cardiovascular Diseases?.

Guieu R, Brignole M, Deharo J, Deharo P, Mottola G, Groppelli A Int J Mol Sci. 2021; 22(14).

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