CNS Organoids: an Innovative Tool for Neurological Disease Modeling and Drug Neurotoxicity Screening

Overview

Journal Drug Discov Today

Specialty Pharmacology

Date 2019 Nov 30

PMID 31783130

Citations 22

Authors

Tanya Chhibber

Sounak Bagchi

Behnaz Lahooti

Angela Verma

Abraham Al-Ahmad

Manash K Paul

Gurudutt Pendyala

Rahul Dev Jayant

Affiliations

Soon will be listed here.

Abstract

The paradigm of central nervous system (CNS) drug discovery has mostly relied on traditional approaches of rodent models or cell-based in vitro models. Owing to the issues of species differences between humans and rodents, it is difficult to correlate the robustness of data for neurodevelopmental studies. With advances in the stem-cell field, 3D CNS organoids have been developed and explored owing to their resemblance to the human brain architecture and functions. Further, CNS organoids provide a unique opportunity to mimic the human brain physiology and serve as a modeling tool to study the normal versus pathological brain or the elucidation of mechanisms of neurological disorders. Here, we discuss the recent application of a CNS organoid explored for neurodevelopment disease or a screening tool for CNS drug development.

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