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Osteoarticular Infections in Pediatrics

Overview
Specialty Pediatrics
Date 2019 Nov 30
PMID 31783013
Citations 13
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Abstract

Objective: To collect the most up-to-date information regarding pediatric osteoarticular infections, including the epidemiological and microbiological profiles, diagnosis, and treatment.

Source Of Data: A non-systematic review was performed on the search engines PubMed, SciELO, LILACS, and Google Scholar, using the keywords "bone and joint infection", "children", "pediatric", "osteomyelitis", "septic arthritis" and "spondylodiscitis" over the last ten years. The most relevant articles were selected by the authors to constitute the database.

Synthesis Of Data: Osteoarticular infections are still a major cause of morbidity in pediatrics. Their main etiology is Staphylococcus aureus, but there has been an increase in the detection of Kingella kingae, especially through molecular methods. Microbiological identification allows treatment direction, while evidence of inflammatory activity assists in treatment follow-up. Imaging tests are especially useful in the initial diagnosis of infections. Empirical treatment should include coverage for the main microorganisms according to the age and clinical conditions of the patient, while considering the local resistance profile. Surgical procedures can be indicated for diagnosis, focus control, and function preservation. Acute complications include sepsis, deep venous thrombosis, and pulmonary embolism. Deaths are rare. Late complications are uncommon but may lead to deformities that compromise motor development.

Conclusion: A correct and early diagnosis, prompt implementation of adequate antimicrobial therapy, and focus control, when indicated, are critical to a better prognosis.

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References
1.
Zunino C, Vomero A, Pandolfo S, Gutierrez C, Algorta G, Pirez M . [Etiology and evolution of the osteoarticular infections. 2009-2015: Pediatric Hospital Pereira Rossell Uruguay]. Rev Chilena Infectol. 2017; 34(3):235-242. DOI: 10.4067/S0716-10182017000300005. View

2.
Paakkonen M, Kallio M, Lankinen P, Peltola H, Kallio P . Preceding trauma in childhood hematogenous bone and joint infections. J Pediatr Orthop B. 2013; 23(2):196-9. DOI: 10.1097/BPB.0000000000000006. View

3.
Riise O, Handeland K, Cvancarova M, Wathne K, Nakstad B, Abrahamsen T . Incidence and characteristics of arthritis in Norwegian children: a population-based study. Pediatrics. 2008; 121(2):e299-306. DOI: 10.1542/peds.2007-0291. View

4.
Lorrot M, Gillet Y, Gras Le Guen C, Launay E, Cohen R, Grimprel E . Antibiotic therapy of bone and joint infections in children: proposals of the French Pediatric Infectious Disease Group. Arch Pediatr. 2018; 24(12S):S36-S41. DOI: 10.1016/S0929-693X(17)30517-1. View

5.
Saavedra-Lozano J, Falup-Pecurariu O, Faust S, Girschick H, Hartwig N, Kaplan S . Bone and Joint Infections. Pediatr Infect Dis J. 2017; 36(8):788-799. DOI: 10.1097/INF.0000000000001635. View