Correlation of Postoperative Splenic Volume Increase with Prognosis of Hepatocellular Carcinoma After Curative Hepatectomy

Overview

Journal Can J Surg

Specialty General Surgery

Date 2019 Nov 30

PMID 31782297

Citations 1

Authors

Jian Lin

Min-Hui Chi

Xiang Zhang

Shan-Geng Weng

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have reported a close connection between the spleen and hepatic tumours. We investigated the prognostic value of postoperative splenic volume increase (PSVI) in patients with hepatocellular carcinoma after curative hepatectomy.

Methods: This was a retrospective study of adult patients with hepatocellular carcinoma who underwent hepatectomy between January 2007 and May 2013. We categorized patients into 2 groups according to the cut-off value of the receiver operating characteristic curve: group A (PSVI < 19.0%) and group B (PSVI ≥ 19.0%). We compared the clinicopathological data, overall survival and disease-free survival between the 2 groups. We performed univariate and multivariate analyses to identify factors associated with disease-free and overall survival.

Results: There were 275 patients in group A and 196 patients in group B. The 1-, 3- and 5-year overall survival rates were 98.9%, 74.9% and 63.6%, respectively, for patients in group A, and 97.4%, 65.3% and 49.8%, respectively, for patients in group B (p = 0.004). The corresponding disease-free survival rates were 69.5%, 48.0% and 40.3%, and 58.1%, 36.5%, and 29.8% (p = 0.01). On multivariate analysis, PSVI was an independent predictor of overall (p = 0.01) and disease-free (p = 0.03) survival.

Conclusion: Postoperative splenic volume increase correlates with poor prognosis of patients with hepatocellular carcinoma after curative hepatectomy.

Citing Articles

The impact of hepatic and splenic volumetric assessment in imaging for chronic liver disease: a narrative review.

Kutaiba N, Chung W, Goodwin M, Testro A, Egan G, Lim R Insights Imaging. 2024; 15(1):146.

PMID: 38886297 PMC: 11183036. DOI: 10.1186/s13244-024-01727-3.

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